Fig 9.

The sheddases BACE and ADAM17 cleave substrates at the extracellular membrane surface. Sheddases belonging to the BACE (A) and ADAM (B) families cleave membrane proteins at aqueous juxtamembrane positions. This results in the release of ectodomains from the substrate proteins into the extracellular space. The catalytic domains of both BACE (PDB accession number 1W50) and ADAM (PDB accession number 1BKC) are shown with zoomed-in views of the active site regions. JMol was used to generate the 3D structure images.