Table 1.
Effects of TgUG2-G2 and TgUG4-G2 on megaureters in Gata2fGN/fGN mice
| Characteristic | Value for the following group of micea: |
||||||
|---|---|---|---|---|---|---|---|
| Gata2+/+ | Gata2fGN/fGN | Gata2fGN/fGN:TgUG2-G2 line 3 | Gata2fGN/fGN:TgUG2-G2 line 10 | Gata2fGN/fGN:TgUG4-G2 line 6 | Gata2fGN/fGN:TgUG4-G2 line 20 | Gata2fGN/fGN:TgUG2-G2 line 3 or 10, Gata2fGN/fGN:TgUG4-G2 line 6 or 20 | |
| No. of ureters examined | 48 | 126 | 50 | 36 | 26 | 44 | 42 |
| No. (%) of ureters moderately distended | 2 (4.2) | 23 (18.3) | 9 (18.0) | 6 (16.6) | 7 (26.9) | 4 (9.1) | 5 (11.9) |
| No. (%) of ureters severely distended | 0 (0) | 33 (26.1) | 13 (26.0) | 10 (27.8) | 1 (3.8**) | 1 (2.3**) | 3 (7.1**) |
| No. (%) of megaureters | 2 (4.2) | 56 (44.4) | 22 (44.0) | 16 (44.4) | 8 (30.7) | 5 (11.4**) | 8 (19.0**) |
a
Transgenic lines 3 and 6 express small amounts of GATA-2, and transgenic lines 10 and 20 express large amounts of GATA-2. Values that are significantly different (P < 0.01 by Mann-Whitney U test) compared to the values for Gata2fGN/fGN littermates are indicated by a pair of asterisks.