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. 2012 Jun;32(12):2239–2253. doi: 10.1128/MCB.06597-11

Fig 11.

Fig 11

Model depicting miR-155-mediated modulation of macrophage apoptosis. M. bovis BCG induces the upregulation of miR-155 by triggering the TLR2/PI3K pathway. PKCδ and RAS-RAF1-MAPKs play vital roles in M. bovis BCG-induced miR-155 expression through transcriptional factors NF-κB and c-ETS. Induced miR-155 targets PKI-α, a negative regulator of PKA signaling, resulting in the robust activation of the PKA signaling pathway. Overall, miR-155 induces the upregulation of proapoptotic genes by modulating PKA signaling, resulting in macrophage apoptosis.