Table 6.
MultiFun cellular function assignments.
| MultiFun Concepts | Frequency of Ontology Annotation | Brief Description | Genes | Gene Products | |||
|---|---|---|---|---|---|---|---|
| Name | Frequency of Assignment | Frequency of Annotation | Name | Frequency of Annotation | |||
| BC-1.7.33 Nucleotide and nucleoside conversions | 76% | The chemical reactions involved in the central carbon metabolism by which a nucleobase, nucleoside or nucleotide is converted from another nucleobase, nucleoside or nucleotide. | relA | 68% | 72% | RelA | 79% |
| spoT | 28% | 46% | SpoT | 31% | |||
| BC-3.1.3.4 Proteases, cleavage of compounds | 55% | Proteins that hydrolysates a peptide bond or bonds within a protein during posttranscriptional regulatory processes. | spoT | 91% | 46% | SpoT | 31% |
| BC-2.2.2 Transcription related functions | 51% | The information transfer related functions involved in the synthesis of RNA on a template of DNA. | fis | 22% | 6% | Fis | 9% |
| rpoB | 17% | 16% | RpoB | 18% | |||
| BC-2.3.2 Translation | 48% | The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. | dksA | 23% | 3% | DksA | 8% |
| rplK | 17% | 6% | RplK | 7% | |||
| rpsG | 12% | 18% | RpsG | NA | |||
| rpsL | 11% | 19% | RpsL | 3% | |||
| BC-5.5.3 Starvation | 47% | A state or activity of a cell or an organism as a result to the adaptation to starvation. | spoT | 85% | 46% | SpoT | 31% |
| dksA | 12% | 3% | DksA | 8% | |||
| BC-1.1.1 Carbon compounds | 46% | The metabolic reactions by which living organisms utilises carbon compounds. | lacZ | 49% | 26% | LacZ | 28% |
| ptsG | 22% | 16% | PtsG | 1% | |||
| BC-2.3.8 Ribosomal proteins | 44% | Proteins that associate to form a ribosome involved in genetic information transfer in cells. | rplK | 24% | 6% | RplK | 7% |
| rpsG | 18% | 18% | RpsG | NA | |||
| rpsL | 17% | 19% | RpsL | 3% | |||
| BC-3.1.2.3 Repressor | 40% | Any transcription regulator that prevents or downregulates transcription. | fis | 41% | 6% | Fis | 9% |
| BC-3.1.2.2 Activator | 32% | Any transcription regulator that induces or upregulates transcription. | fis | 45% | 6% | Fis | 9% |
MultiFun terms were assigned to annotated concepts associated with genes. A threshold of 30% of documents was considered for ontology assignment and a threshold of 10% was used to point out the genes that most contributed to such assignment.
NA: corresponds to non-annotated gene products in the corpus.