Table 8.
Assignment of GO concepts related to stress responses.
| Frequency of Ontology Annotation | ||||||
|---|---|---|---|---|---|---|
| GO Identifier | GO Concept | GO Description | 1970 | 1980 | 1990 | 2000 |
| GO:0042594 | Response to starvation | A change in state or activity of a cell or an organism as a result of a starvation stimulus, deprivation of nourishment. | - | 15% | 28% | 68% |
| GO:0006974 | Response to DNA damage stimulus | A change in state or activity of a cell or an organism as a result of a stimulus indicating damage to its DNA. | 7% | 26% | 31% | 50% |
| GO:0006970 | Response to osmotic stress | A change in state or activity of a cell as a result of an increase or decrease in the concentration of solutes outside the cell. | 21% | 28% | 35% | 50% |
| GO:0006950 | Response to stress | A change in state or activity of a cell or an organism as a result of a disturbance in organismal or cellular homeostasis. | - | 31% | 46% | 46% |
| GO:0006979 | Response to oxidative stress | A change in state or activity of a cell or an organism as a result of oxidative stress. | - | 3% | 20% | 45% |
| GO:0009432 | SOS response | An error-prone process for repairing damaged microbial DNA. | - | 23% | 30% | 45% |
| GO:0046677 | Response to antibiotic | A change in state or activity of a cell or an organism as a result of an antibiotic stimulus. | - | 23% | 30% | 15% |
| GO:0042493 | Response to drug | A change in state or activity of a cell or an organism as a result of a drug stimulus. | - | 15% | 35% | 11% |
| GO:0009266 | Response to temperature stimulus | A change in state or activity of a cell or an organism as a result of a temperature stimulus. | - | - | 9% | 11% |
| GO:0042742 | Defense response to bacterium | Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism. | 14% | 26% | 9% | 8% |
| GO:0015968 | Stringent response | A specific global change in the metabolism of a bacterial cell as a result of starvation. | - | 13% | 7% | 6% |
| GO:0009408 | Response to heat | A change in state or activity of a cell or an organism as a result of a heat stimulus. | - | 3% | 13% | 5% |
| GO:0009409 | Response to cold | A change in state or activity of a cell or an organism as a result of a cold stimulus. | - | - | - | 3% |
| GO:0009636 | Response to toxin | A change in state or activity of a cell or an organism as a result of a toxin stimulus. | - | - | - | 3% |
| GO:0009267 | Cellular response to starvation | A change in state or activity of a cell as a result of deprivation of nourishment. | - | - | - | 1% |
| GO:0046688 | Response to copper ion | A change in state or activity of a cell or an organism as a result of a copper ion stimulus. | - | - | - | 1% |
| GO:0009269 | Response to desiccation | A change in state or activity of a cell or an organism as a result of a desiccation stimulus. | - | - | 4% | - |
| GO:0031427 | Response to methotrexate | A change in state or activity of a cell or an organism as a result of a methotrexate stimulus. | - | - | 2% | - |
The frequency of annotation of stress response-related concepts was estimated for documents published in the four decades analysed (from 1970 to 2009).