Table 3.

Associations Between Baseline Urinary Arsenic (μg/g Creatinine) and Plasma Levels of MMP-9, Myeloperoxidase, PAI-1, Soluble E-Selectin, Soluble ICAM-1, and Soluble VCAM-1, Health Effects of Arsenic Longitudinal Study, Bangladesh, 2007–2008^a

	Baseline Concentrations of Urinary Arsenic (μg/g Creatinine) in Quartiles								Per Log-transformed Urinary Arsenic (μg/g Creatinine)b
	12.05–88.21 (n = 163)		88.22–141.69 (n = 163)		141.70–275.63 (n = 161)		275.64–1,869.57 (n = 163)
	Exp (β)	95% CI	Exp (β)	95% CI	Exp (β)	95% CI	Exp (β)	95% CI	Exp (β)	95% CI
Meanc	57.53		115.11		203.91		542.70
MMP-9, ng/mL
Model 1d	1.00	Reference group	0.87	0.77, 0.98	0.83	0.74, 0.94	0.91	0.80, 1.03	0.96	0.92, 1.01
Model 2e	1.00	Reference group	0.89	0.79, 1.01	0.86	0.76, 0.97	0.95	0.84, 1.08	0.98	0.93, 1.03
Myeloperoxidase, ng/mL
Model 1d	1.00	Reference group	0.85	0.75, 0.97	0.89	0.78, 1.01	0.89	0.79, 1.02	0.97	0.92, 1.02
Model 2e	1.00	Reference group	0.87	0.76, 0.99	0.91	0.80, 1.03	0.92	0.81, 1.05	0.98	0.93, 1.03
PAI-1, ng/mL
Model 1d	1.00	Reference group	0.92	0.81, 1.04	0.90	0.80, 1.02	1.04	0.92, 1.17	1.02	0.97, 1.07
Model 2e	1.00	Reference group	0.96	0.85, 1.09	0.95	0.84, 1.07	1.11	0.90, 1.26	1.05	1.00, 1.11
Soluble E-selectin, ng/mL
Model 1d	1.00	Reference group	0.94	0.86, 1.04	0.89	0.81, 0.98	0.95	0.87, 1.05	0.99	0.95, 1.02
Model 2e	1.00	Reference group	0.96	0.88, 1.06	0.92	0.84, 1.01	0.99	0.90, 1.09	1.00	0.96, 1.04
Soluble ICAM-1, ng/mL
Model 1d	1.00	Reference group	0.93	0.80, 1.08	0.98	0.85, 1.14	1.02	0.88, 1.19	1.02	0.96, 1.08
Model 2e	1.00	Reference group	0.92	0.79, 1.06	0.96	0.83, 1.11	1.00	0.86, 1.16	1.01	0.95, 1.07
Soluble VCAM-1, ng/mL
Model 1d	1.00	Reference group	1.03	0.96, 1.11	1.10	1.03, 1.18	1.12	1.05, 1.20	1.05	1.02, 1.08
Model 2e	1.00	Reference group	1.02	0.95, 1.09	1.08	1.01, 1.16	1.09	1.02, 1.17	1.04	1.01, 1.07

Abbreviations: CI, confidence interval; Exp (β), exponentiated regression coefficient; ICAM-1, intercellular adhesion molecule-1; MMP-9, matrix metalloproteinase-9; PAI-1, plasminogen activator inhibitor-1; VCAM-1, vascular adhesion molecule-1.

^aModels were run with log-transformed MMP-9, myeloperoxidase, PAI-1, soluble E-selectin, soluble ICAM-1, and soluble VCAM-1.

^bComputed with the log-transformed arsenic level entered as a continuous variable in the linear regression models.

^cCategory-specific mean values of urinary arsenic.

^dAdjusted for sex and age (years).

^eAdjusted for sex, age, body mass index, education, and smoking status (never vs. ever).