Table 2.

Risk of Acoustic Neuroma in Relation to Regular Cigarette Smoking, Sweden, 2002–2007^a,b

Factor	Men						Women						All
	Cases		Controls		ORc	95% CI	Cases		Controls		ORd	95% CI	Cases		Controls		ORd	95% CI
	No.	%	No.	%			No.	%	No.	%			No.	%	No.	%
Ever regular smoker
No	127	54.98	168	46.93	1.0e		106	55.50	148	52.48	1.0e		233	55.21	316	49.38	1.0e
Yes	104	45.02	190	53.07	0.73	0.51, 1.05	85	44.50	134	47.52	0.88	0.59, 1.29	189	44.79	324	50.63	0.80	0.61, 1.04
Smoking status
Former smoker	85	36.80	125	34.92	0.97	0.64, 1.46	59	30.89	81	28.72	0.98	0.63, 1.50	144	34.12	206	32.19	0.98	0.73, 1.32
Current smokerf	19	8.23	63	17.60	0.41	0.23, 0.74	26	13.61	52	18.44	0.70	0.40, 1.23	45	10.66	115	17.97	0.54	0.36, 0.81
Age started smoking, years
<15	15	6.49	16	4.47	1.45	0.64, 3.32	6	3.14	23	8.16	0.41	0.16, 1.05	21	4.98	39	6.09	0.82	0.46, 1.47
15–19	62	26.84	129	36.03	0.64	0.42, 0.97	49	25.65	69	24.47	1.00	0.64, 1.57	111	26.30	198	30.94	0.78	0.57, 1.05
≥20	27	11.67	45	12.57	0.73	0.42, 1.27	30	15.71	42	14.89	0.96	0.53, 1.75	57	13.51	87	13.59	0.84	0.56, 1.26
Ptrend (all subjects)					0.09						0.32						0.41
Ptrend (ever smokers)					0.95						0.04						0.20
Years since started smoking
<20	7	3.03	9	2.51	1.16	0.42, 3.20	7	3.66	11	3.90	1.09	0.39, 3.02	14	3.32	20	3.13	1.13	0.55, 2.33
20–29	9	3.90	20	5.59	0.54	0.22, 1.37	10	5.24	18	6.38	0.75	0.32, 1.77	19	4.50	38	5.94	0.62	0.33, 1.18
30–39	36	15.58	61	17.04	0.74	0.43, 1.27	40	20.94	56	19.86	1.07	0.62, 1.85	76	18.01	117	18.28	0.89	0.61, 1.31
≥40	52	22.51	100	27.93	0.68	0.42, 1.11	28	14.66	49	17.38	0.68	0.37, 1.26	80	18.96	149	23.28	0.70	0.48, 1.02
Ptrend (all subjects)					0.38						0.69						0.25
Ptrend (ever smokers)					0.90						0.95						0.91
Total years smoked
<10	25	10.82	40	11.17	0.83	0.47, 1.48	18	9.42	29	10.28	0.94	0.49, 1.81	43	10.19	69	10.78	0.90	0.59, 1.38
10–19	28	12.12	36	10.06	1.05	0.58, 1.90	21	10.99	26	9.22	1.14	0.59, 2.21	49	11.61	62	6.69	1.09	0.70, 1.70
20–29	18	7.79	36	10.06	0.71	0.37, 1.35	12	6.28	28	9.93	0.58	0.28, 1.19	30	7.11	64	10.00	0.66	0.40, 1.07
≥30	29	12.55	68	18.99	0.54	0.32, 0.93	28	14.66	43	15.25	0.78	0.43, 1.43	57	13.51	111	17.34	0.64	0.43, 0.96
Ptrend (all subjects)					0.20						0.56						0.11
Ptrend (ever smokers)					0.50						0.56						0.33
Years since stopped smoking
≥30	20	8.66	26	7.26	1.18	0.60, 2.32	9	4.71	11	3.90	1.32	0.48, 3.66	29	6.87	37	5.78	1.24	0.71, 2.18
20–29	28	12.12	36	10.06	1.07	0.58, 1.97	18	9.42	23	8.16	1.12	0.56, 2.24	45	10.66	59	9.22	1.12	0.71, 1.76
10–19	19	8.23	39	10.89	0.73	0.39, 1.38	12	6.28	24	8.51	0.73	0.35, 1.52	31	7.35	31	4.84	0.74	0.46, 1.19
5–9	9	3.90	12	3.35	0.97	0.38, 2.51	8	4.19	13	4.61	0.69	0.27, 1.78	17	4.03	17	2.66	0.78	0.39, 1.54
>1–4	7	3.03	10	2.79	1.00	0.36, 2.78	8	4.19	8	2.84	1.54	0.52, 4.57	15	3.55	14	2.19	1.22	0.58, 2.56
Current smokere	19	8.23	63	17.60	0.43	0.24, 0.77	26	13.61	52	18.44	0.71	0.40, 1.26	45	10.66	115	17.97	0.56	0.37, 0.84
Ptrend (ever smokers)					0.05						0.56						0.12
Smoking pack-years
<10	44	19.05	70	19.55	0.83	0.51, 1.34	41	21.47	55	19.50	1.06	0.65, 1.71	85	20.14	125	19.53	0.96	0.68, 1.34
10–19	31	13.42	42	11.73	0.99	0.58, 1.69	17	8.90	38	13.48	0.55	0.29, 1.06	48	11.37	80	12.50	0.78	0.51, 1.17
20–29	9	3.90	31	8.66	0.36	0.15, 0.82	13	6.81	16	5.67	1.17	0.52, 2.62	22	5.21	47	7.34	0.64	0.37, 1.12
≥30	16	6.93	33	99.22	0.54	0.27, 1.08	7	3.66	15	5.32	0.53	0.20, 1.46	23	5.45	48	7.50	0.58	0.33, 1.01
Ptrend (all subjects)					0.10						0.29						0.20
Ptrend (ever smokers)					0.24						0.43						0.13

Abbreviations: CI, confidence interval; OR, odds ratio.

^aSmoking is defined as at least 1 cigarette daily for 6 months or longer.

^bThe number of observations throughout the table varies by smoking category because of missing values. Each factor in the table represents a different regression coefficient with different covariates.

^cOdds ratios from conditional logistic regression models stratified by matched set. Cases and controls were matched on gender, age (within 5 years at the reference date), and region. Odds ratios were adjusted for the highest level of education and snuff use (never vs. ever).

^dOdds ratios for women were similarly constructed but were not adjusted for snuff use because of lack of snuff users in the population.

^eReference category for the entire table.

^fCurrent smoker odds ratios are not identical because they are based on the regressions with different covariates.