Table 3.

Risk of Head and Neck Cancer According to Quartile of Dietary Pattern (Determined Among Control Subjects), Overall and by Cancer Site, CHANCE Study, North Carolina, 2002–2006

Dietary Pattern	No. of Controls	Overall			Oral/Pharyngeal Cancer			Laryngeal Cancer
		No. of Cases	ORa	95% CI	No. of Cases	OR	95% CI	No. of Cases	OR	95% CI
Fruits, vegetables, and lean protein
Q1	329	505	1		325	1		180	1
Q2	329	294	0.77	0.60, 1.00	186	0.77	0.59, 1.01	108	0.78	0.56, 1.09
Q3	329	221	0.71	0.54, 0.94	148	0.71	0.52, 0.95	73	0.70	0.48, 1.03
Q4	330	156	0.53	0.39, 0.71	98	0.45	0.32, 0.63	58	0.73	0.48, 1.10
P-trend		<0.0005			<0.0005			0.08
P-heterogeneityb	0.24
Fried foods, high-fat and processed meats, and sweets
Q1	329	133	1		101	1		32	1
Q2	329	179	0.94	0.69, 1.29	126	0.90	0.64, 1.26	53	1.10	0.66, 1.83
Q3	329	264	1.02	0.74, 1.42	164	0.86	0.60, 1.24	100	1.53	0.93, 2.52
Q4	330	600	1.24	0.84, 1.82	366	0.96	0.63, 1.47	234	2.12	1.21, 3.72
P-trend		0.02			<0.005			0.01
P-heterogeneity	0.05

Abbreviations: CHANCE, Carolina Head and Neck Cancer Epidemiology; CI, confidence interval; OR, odds ratio; Q, quartile.

^aOdds ratios were adjusted for matching strata (gender, race, age), total energy intake (continuous), tobacco use (number of years of cigarette smoking: never, 1–19, 20–39, or ≥40), beer consumption (number of 12-ounce (0.4-L) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), liquor consumption (number of 1.5-ounce (44.4-mL) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), and education (high school or less, some college, college or more).

^bP value for test of heterogeneity of effect across tumor sites, assessed using the likelihood ratio test and a multinomial logistic regression model.