Table 4.

Effect Modification of the Association of the Fruit, Vegetable, and Lean Protein Dietary Pattern With Risk of Head and Neck Squamous Cell Carcinoma by Anthropometric, Sociodemographic, and Lifestyle Factors, CHANCE Study, North Carolina, 2002–2006

	No. of Controls	No. of Cases	Quartile of Fruit, Vegetable, and Lean Protein Dietary Pattern							Ptrenda	Pinteractionb
			Q1	Q2		Q3		Q4
				ORc	95% CI	OR	95% CI	OR	95% CI
Body mass indexd											0.24
<25	496	474	1	0.61	0.40, 0.94	0.49	0.30, 0.79	0.41	0.25, 0.67	<0.0005
≥25	909	742	1	0.88	0.65, 1.19	0.85	0.61, 1.18	0.58	0.41, 0.83	<0.0005
Gender											0.28
Male	909	899	1	0.88	0.60, 1.18	0.79	0.58, 1.08	0.55	0.38, 0.79	<0.0005
Female	408	277	1	0.51	0.30, 0.85	0.52	0.31, 0.89	0.42	0.25, 0.70	<0.0005
Race											0.14
White	1,054	880	1	0.87	0.60, 1.16	0.74	0.55, 1.01	0.58	0.42, 0.81	<0.0005
Black	246	274	1	0.50	0.27, 0.82	0.58	0.32, 1.07	0.28	0.14, 0.59	<0.0005
Smoking duration, years											0.18
Never smoker	505	160	1	1.08	0.63, 1.85	0.88	0.51, 1.50	0.39	0.21, 0.71	<0.0005
<1–19	281	110	1	0.74	0.38, 1.45	0.74	0.38, 1.44	0.40	0.20, 0.83	0.03
≥20	528	904	1	0.67	0.50, 0.92	0.56	0.39, 0.78	0.56	0.38, 0.81	<0.0005
Liquor consumption, drinks/day											0.99
0	462	246	1	0.71	0.45, 1.13	0.63	0.37, 1.06	0.50	0.28, 0.80	0.001
<1–4	556		1	0.81	0.54, 1.22	0.76	0.50, 1.15	0.55	0.35, 0.86	0.002
≥5	292	529	1	0.78	0.51, 1.20	0.73	0.45, 1.15	0.51	0.31, 0.85	0.005
Beer consumption, drinks/day											0.50
0	478	222	1	0.58	0.35, 0.96	0.65	0.39, 1.08	0.41	0.24, 0.70	<0.0005
<1–4	466	275	1	0.66	0.42, 1.04	0.57	0.36, 0.94	0.46	0.28, 0.75	0.001
≥5	367	672	1	0.96	0.66, 1.38	0.82	0.54, 1.24	0.61	0.38, 0.96	0.007

Abbreviations: CHANCE, Carolina Head and Neck Cancer Epidemiology; CI, confidence interval; OR, odds ratio; Q, quartile.

^aP value from test for linear trend.

^bP value from likelihood ratio test of interaction.

^cOdds ratios were adjusted for matching strata (gender, race, age), total energy intake (continuous), tobacco use (number of years of cigarette smoking: never, 1–19, 20–39, or ≥40), beer consumption (number of 12-ounce (0.4-L) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), liquor consumption (number of 1.5-ounce (44.4-mL) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), and education (high school or less, some college, college or more). Models for interaction by smoking duration, liquor consumption, and beer consumption included only the grouped version of the respective variable.

^dWeight (kg)/height (m)².