Table 5.
Effect Modification of the Association of the Fried Foods, High-Fat and Processed Meats, and Sweets Dietary Pattern With Risk of Head and Neck Squamous Cell Carcinoma by Anthropometric, Sociodemographic, and Lifestyle Factors, CHANCE Study, North Carolina, 2002–2006
| No. of ontrols | No. of Cases | Quartile of Fried Foods, High-Fat and Processed Meats, and Sweets Dietary Pattern | Ptrenda | Pinteractionb | |||||||
| Q1 | Q2 | Q3 | Q4 | ||||||||
| ORc | 95% CI | OR | 95% CI | OR | 95% CI | ||||||
| Body mass indexd | |||||||||||
| <25 | 496 | 474 | 1 | 0.65 | 0.39, 1.08 | 0.85 | 0.51, 1.43 | 0.89 | 0.52, 1.52 | 0.19 | 0.13 |
| ≥25 | 909 | 742 | 1 | 1.20 | 0.81, 1.77 | 1.27 | 0.86, 1.88 | 1.70 | 1.10, 2.62 | 0.004 | |
| Gender | |||||||||||
| Male | 909 | 899 | 1 | 0.98 | 0.67, 1.43 | 1.11 | 0.75, 1.62 | 1.38 | 0.90, 2.12 | 0.01 | 0.99 |
| Female | 408 | 277 | 1 | 0.94 | 0.55, 1.59 | 1.08 | 0.64, 1.84 | 1.25 | 0.70, 2.24 | 0.17 | |
| Race | |||||||||||
| White | 1,054 | 880 | 1 | 0.93 | 0.67, 1.30 | 1.11 | 0.79, 1.57 | 1.31 | 0.88, 1.95 | 0.02 | 0.65 |
| Black | 246 | 274 | 1 | 1.44 | 0.54, 3.83 | 1.22 | 0.49, 3.04 | 1.92 | 0.81, 4.58 | 0.05 | |
| Smoking duration, years | |||||||||||
| Never smoker | 505 | 160 | 1 | 0.77 | 0.45, 1.32 | 0.68 | 0.39, 1.19 | 0.97 | 0.54, 1.75 | 0.65 | 0.45 |
| <1–19 | 281 | 110 | 1 | 1.08 | 0.53, 2.17 | 1.10 | 0.54, 2.22 | 1.20 | 0.60, 2.41 | 0.36 | |
| ≥20 | 528 | 904 | 1 | 1.17 | 0.76, 1.80 | 1.51 | 0.99, 2.32 | 1.94 | 1.23, 3.07 | <0.0005 | |
| Liquor consumption, drinks/day | |||||||||||
| 0 | 462 | 246 | 1 | 0.79 | 0.43, 1.45 | 1.19 | 0.66, 2.13 | 1.30 | 0.70, 2.40 | 0.13 | 0.69 |
| <1–4 | 556 | 396 | 1 | 1.02 | 0.66, 1.58 | 1.07 | 0.68, 1.67 | 1.13 | 0.70, 1.83 | 0.32 | |
| ≥5 | 292 | 529 | 1 | 1.10 | 0.60, 2.04 | 1.04 | 0.58, 1.86 | 1.66 | 0.92, 2.98 | 0.002 | |
| Beer consumption, drinks/day | |||||||||||
| 0 | 478 | 222 | 1 | 1.13 | 0.63, 2.06 | 1.31 | 0.73, 2.32 | 1.82 | 1.01, 3.30 | 0.005 | 0.47 |
| <1–4 | 466 | 275 | 1 | 1.16 | 0.71, 1.91 | 1.28 | 0.77, 2.13 | 1.28 | 0.75, 2.17 | 0.31 | |
| ≥5 | 367 | 672 | 1 | 0.67 | 0.39, 1.14 | 0.80 | 0.48, 1.34 | 1.02 | 0.60, 1.76 | 0.05 | |
Abbreviations: CHANCE, Carolina Head and Neck Cancer Epidemiology; CI, confidence interval; OR, odds ratio; Q, quartile.
P value from test for linear trend.
P value from likelihood ratio test of interaction.
Odds ratios were adjusted for matching strata (gender, race, age), total energy intake (continuous), tobacco use (number of years of cigarette smoking: never, 1–19, 20–39, or ≥40), beer consumption (number of 12-ounce (0.4-L) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), liquor consumption (number of 1.5-ounce (44.4-mL) servings per week: none, <1, 1–4, 5–14, 15–29, or ≥30), and education (high school or less, some college, college or more). Models for interaction by smoking duration, liquor consumption, and beer consumption included only the grouped version of the respective variable.
Weight (kg)/height (m)2.