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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Jun 22;187(3):1150–1156. doi: 10.4049/jimmunol.1004077

Figure 1. Liver bulk T cells are suppressed following BDL.

Figure 1

B6 mice underwent bile duct ligation (BDL), sham laparotomy (SHAM), or no treatment (NO TX). After 7 days, T cells were stimulated with DC. Bulk liver (A) but not spleen (B) T cell function in MLR was suppressed by BDL. Similar findings were noted when liver T cells from OT-II mice 7 days after BDL were stimulated with OVA-loaded syngeneic DC (C). The conventional CD4 (CD25-NK1.1-CD1d/αGalCer-γδ-) T cell response to allogeneic DC was not affected by BDL (D). Proliferation of T cells or DC cultured alone was negligible. Means and standard deviations are shown based on triplicate wells and the data are representative of 3 or more repetitions with 3 or more livers pooled per group. *p<0.05