Figure 1. Comparison of the efficacy of MK-8776 to abrogate SN38-induced S and G₂ arrest in p53 wild-type cell lines. Cell were incubated with 10 ng/ml SN38 for 24 h and then incubated in either media with or without 1 µM MK-8776. Cells were harvested and assayed for DNA content by flow cytometry.