Figure 1.

PPAR-α expression in spinal cord tissues. A basal level of PPAR-α was detected in the spinal cord tissues from shamWT-operated mice, whereas in SCI-operated PPARαWT mice the levels were substantially reduced (panels A and A1). Simvastatin treatment significantly reversed the spinal PPAR-α levels down-regulated by SCI (panels A and A1). The relative expression of the protein bands was standardized for densitometric analysis to lamin levels, reported in panel a1, and expressed as mean ± s.e.m. from n = 5/6 spinal cord for each group. *P < 0.01 versus sham, °P < 0.01 versus SCI+vehicle.