Table 1.
Patient characteristics and distribution of DR4 genotypes
| Healthy controls | HCV(+) all without HCC | HCV(+) Cirrhosis (-) Without HCC | HCV(+) Cirrhosis (+) without HCC | HCV(+) Cirrhosis (+) with HCC | HBV(+) With HCC | |
|---|---|---|---|---|---|---|
| Numbers | 359 | 234 | 159 | 75 | 159 | 56 |
| Median age (range) | 59 (35-69) | 52 (39-63) | 46 (39-57) | 55 (49-63) | 62 (54-70) | 60(24-83) |
| Male Gender (%) | 51.4 | 66.2 | 65.2 | 69.7 | 58.6 | 75.0 |
| HCV infection (%) | - | 100 | 100 | 100 | 100 | 0 |
| HCV genotype 1 (%) | - | 100 | 100 | 100 | 100 | - |
| HCV viral load(106 IU/ml) a) | - | 2.04 ± 0.25 | 2.10 ± 0.29 | 1.86 ± 0.48 | 1.88 ± 0.36 | - |
| HBV infection (%) | - | 3.2 | 2.8 | 4.0 | 4.4 | 100 |
| BMI > 30 (%) | - | 17.1 | 15.0 | 21.7 | 26.2 | 21.4 |
| Diabetes (%) | - | 7.7 | 0.8 | 23.0 | 12.0 | 3.6 |
| rs20575 (C626G) b) | 349 (100) | 233 (100) | 159 (100) | 74 (100) | 159 (100) | 56 (100) |
| CC | 62 (17.8) | 56 (24.0) | 38 (23.9) | 18 (24.3) | 40 (25.2) | 9 (16.1) |
| CG | 166 (47.6) | 108 (46.4) | 74 (46.5) | 34 (45.9) | 87 (54.7) | 30 (53.6) |
| GG | 121 (34.7) | 69 (29.6) | 47 (29.6) | 22 (29.7) | 32 (20.1) | 17 (30.4) |
| Deviation from Hardy-Weinberg equilibrium c) | p = 0.74 | p = 0.29 | p = 0.43 | p = 0.49 | p = 0.27 | p = 0.59 |
| rs20576 (A683C) b) | 359 (100) | 234 (100) | 159 (100) | 75 (100) | 159 (100) | 56 (100) |
| CC | 19 (5.3) | 10 (4.3) | 6 (3.8) | 4 (5.3) | 5 (3.1) | 1 (1.8) |
| AC | 125 (34.8) | 85 (36.3) | 59 (35.0) | 26 (34.7) | 33 (21.9) | 17 (30.4) |
| AA | 215 (59.9) | 139 (59.4) | 94 (59.1) | 45 (60.0) | 121 (75.8) | 38 (67.9) |
| Deviation from Hardy-Weinberg equilibrium c) | p = 0.88 | p = 0.58 | p = 0.49 | p = 1.0 | p = 0.17 | p = 1.0 |
a) Mean ± SEM, b) Number of patients (number/% of total), c) Fisher's exact test