TABLE 2.

Phenotypes of mice lacking protein arginine methyltransferases

Gene	Phenotype(s)
Prmt1	Embryonic lethal, but ES cells can survive
	Trapping mutant generates a hypomorphic allele
Prmt2	Mice are viable
	Mouse embryo fibroblasts have increased activity of NF-kappaB and are more resistant to apoptosis than wild type cells
Prmt3	Mice are viable, but mutant embryos are slightly smaller
	Trapping mutant generates a hypomorphic allele
Carm1/Prmt4	Newborns small and die shortly after birth
	T cell development blocked in thymus
	Lipid metabolism altered in embryos