Figure 3. Simvastatin impairs neutrophil adhesion.

Isolated human neutrophils were pre-treated with simvastatin (3 hours, 1 or 10 µM) and then activated with fMLP. Neutrophils were perfused over immobilized recombinant ICAM-1 or fibronectin at 1 dyne/cm² and the number of adherent cells was enumerated. n = 8–10 for flow chamber experiments (repetition of the experiment = 4). Statistical significance was tested using one way ANOVA with Newman-Keuls Multiple Comparison test.* indicates significant difference of fMLP treated samples compared to each other samples.