Table 1. Amplitudes of retinal Per1::luc or PER2::LUC rhythms in mice of different genotypes.
Gene | Genotype | Rhythmic power(Mean ± SEM) | P value | Statistical analysis | Sample number |
Per1 | Per1+/+ | 667±29 (c) | One-way ANOVAwith Fisher’s LSDpost hoc test | 10 | |
Per1+/− | 509±17 (b) | P<0.001 | 12 | ||
Per1−/− | 229±13 (a) | P<0.001 | 12 | ||
Per2 | Per2+/+ | 275±18 | One-way ANOVAwith Fisher’s LSDpost hoc test | 13 | |
Per2+/− | 263±24 | P>0.05 | 16 | ||
Per2−/− | 214±24 | P>0.05 | 10 | ||
Per3 | Per3+/+ | 647±47 | One-way ANOVAwith Fisher’s LSDpost hoc test | 12 | |
Per3+/− | 722±36 | P>0.05 | 10 | ||
Per3−/− | 676±70 | P>0.05 | 10 | ||
Cry1 & Cry2 | Cry1+/+Cry2+/+ | 618±13 (b) | NonparametricKruskal-Wallis testfollowed by Dunnett'sT3 post hoc test | 10 | |
Cry1+/−Cry2+/+ | 483±43 | P>0.05 | 8 | ||
Cry1−/−Cry2+/+ | 313±22 (a) | P<0. 01 | 14 | ||
Cry1+/+Cry2+/− | 692±16 (b) | P>0.05 | 10 | ||
Cry1+/−Cry2+/− | 612±30 | P>0.05 | 13 | ||
Cry1−/−Cry2+/− | 321±29 (a) | P<0. 01 | 20 | ||
Cry1+/+Cry2−/− | 759±13 (b) | P>0.05 | 12 | ||
Cry1+/−Cry2−/− | 719±19 (b) | P>0.05 | 22 | ||
Cry1−/−Cry2−/− | 166±8 (a) | P<0.001 | 14 | ||
Clock | Clock+/+ | 646±13 (c) | One-way ANOVAwith Fisher’s LSDpost hoc test | 10 | |
Clock+/− | 486±20 (b) | P<0.001 | 10 | ||
Clock−/− | 210±15 (a) | P<0.001 | 8 |
Letters indicate significant difference with a<b<c. P values are for comparisons to wild-type mice. A minimum of three animals were sampled for each genotype.