Table 3. Amplitudes of SCN Per1::luc or PER2::LUC rhythms in mice of different genotypes.
Gene | Genotype | Rhythmic power (Mean ± SEM) | P value | Statistical analysis | Sample number |
Per1 | Per1+/+ | 723±41 (c) | One-way ANOVAwith Fisher’s LSDpost hoc test | 3 | |
Per1+/− | 468±63 (b) | P<0.05 | 6 | ||
Per1−/− | 296±25 (a) | P<0.001 | 4 | ||
Per2 | Per2+/+ | 804±36 (b) | One-way ANOVAwith Fisher’s LSDpost hoc test | 3 | |
Per2+/− | 820±28 (b) | P>0.05 | 4 | ||
Per2−/− | 609±66 (a) | P<0.05 | 3 | ||
Per3 | Per3+/+ | 689±43 | One-way ANOVAwith Fisher’s LSDpost hoc test | 3 | |
Per3+/− | 648±14 | P>0.05 | 3 | ||
Per3−/− | 804±8 | P>0.05 | 3 | ||
Cry1 & Cry2 | Cry1+/+Cry2+/+ | 660±13 (b) | NonparametricKruskal-Wallis testfollowed by Dunnett’sT3 post hoc test | 5 | |
Cry1+/−Cry2+/+ | 464±104 | P>0.05 | 4 | ||
Cry1−/−Cry2+/+ | 393±17 (a) | P<0.05 | 3 | ||
Cry1+/+Cry2+/− | 733±39 (b) | P>0.05 | 6 | ||
Cry1+/−Cry2+/− | 689±28 (b) | P>0.05 | 6 | ||
Cry1−/−Cry2+/− | 344±15 (a) | P<0.01 | 4 | ||
Cry1+/+Cry2−/− | 592±164 | P>0.05 | 3 | ||
Cry1+/−Cry2−/− | 569±76 | P>0.05 | 4 | ||
Cry1−/−Cry2−/− | 168±11 (a) | P<0.001 | 4 | ||
Clock | Clock+/+ | 628±26 | One-way ANOVAwith Fisher’s LSDpost hoc test | 3 | |
Clock+/− | 662±80 | P>0.05 | 5 | ||
Clock−/− | 435±32 | P>0.05 | 3 |
Letters indicate significant difference with a<b<c. P values are for comparisons to wild-type mice. A minimum of three animals were sampled for each genotype.