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. 2012 Jun 11;7(6):e38580. doi: 10.1371/journal.pone.0038580

Figure 4. Consistent effects of IL-10 and IL-15 across numerous donors.

Figure 4

(A) Titration curves depict the effects of adding IL-10 or IL-15 to donor NK cells from three donors, which were all stimulated with the same HIV+ plasma in the presence of HIV-1 Env antigen. (B) NK cells from a common donor were stimulated with plasma from 9 HIV-infected individuals in the presence of HIV-1 Env antigen, with or without exogenous cytokines. Graphs on the top demonstrate the consistency of the effect of exogenous IL-10 and IL-15 on bifunctional (IFNγ+CD107a+) response profiles, regardless of the source of the plasma. Graphs on the bottom depict the consistency of the effect of exogenous IL-10 (50 ng/ml) and IL-15 (5 ng/ml) on the percentage contribution bifunctional responses make to the total NK cell response.