. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2012 Apr 20;21(6):988–992. doi: 10.1158/1055-9965.EPI-12-0166

Table 1.

EGFR Gene Mutations in Never and Former Smoking Lung Cancer Patients

Patient ID	Histology	EGFRexon	Mutation Type	Codon(s)	Nucleotide Change	Amino Acid Change
Missouri Women
2	adenocarcinoma	19	Deletion	del Glu746-Ala750
6	other/mixed	21	Point	858	CTG>CGG	Leu>Arg
48	small cell carcinoma	21	Point	866	GAG>GAT	Glu>Asp
54	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
56	adenocarcinoma	19	Deletion	del Glu746-Ala750
57	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
60	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
69	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
71	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
72	adenocarcinoma	19	Deletion	del Glu746-Ala750
74	adenocarcinoma	21	Point	833	TTG>TTT	Leu>Phe
76	adenocarcinoma	19	Deletion plus insertion	del Leu747-Pro753 (ins Ser)^a
78	adenocarcinoma	19	Deletion plus insertion	del Leu747-Ala750 (ins Pro)^a
81	adenocarcinoma	19	Point	743	GCT>ACT	Ala>Thr
88	adenocarcinoma	21	Point (silent)	858 (silent)	CTG>CTT	Leu>Leu
95	adenocarcinoma	19	Deletion	del Glu746-Ala750
104	adenocarcinoma	21	Point	864	GCG>GTG	Ala>Val
105	adenocarcinoma	19	Deletion	del Glu746-Ala750
126	adenocarcinoma	19	Deletion	del Glu746-Ala750
129	bronchioloalveolar carcinoma	19	Deletion	del Glu746-Ala750
134	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
135	bronchioloalveolar carcinoma	19	Deletion plus insertion	del Glu746-Ser752 (ins Val)^a
136	adenocarcinoma	21	Point (silent)	848 (silent)	CCG>CCT	Pro>Pro
139	other/mixed	19	Deletion	del Ser752 -Ile759

Mayo Clinic Study
	adenosquamous
921901995	carcinoma	21	Point	858	CTG>CGG	Leu>Arg
921901997	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902006	bronchioloalveolar carcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902011	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902017	adenosquamous carcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902018	adenocarcinoma bronchioloalveolar	19	Deletion	del Glu746-Ala750
921902021	carcinoma	19	Deletion plus insertion	del Leu747-Pro753 (ins Ser)^a
921902023	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902024	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902032	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902033	adenosquamous carcinoma	19	Deletion	del Glu746-Ala750
921902049	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902055	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902063	adenocarcinoma	19	Deletion plus insertion	del Leu747-Ala750 (ins Pro)^a
921902067	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902070	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902071	adenocarcinoma	19	Deletion plus insertion	del Glu746-Thr751 (ins Val)^a
921902084	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902086	bronchioloalveolar carcinoma	19	Deletion	del Glu746-Ala750
921902118	adenosquamous carcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902119	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902121	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902132	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902140	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902148	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902154	adenocarcinoma	19	Deletion	del Glu746-Ala750
921902157	squamous cell carcinoma	19	Deletion	del Glu746-Ala750
921902160	squamous cell carcinoma	19	Deletion	del Glu746-Ala750
921902161	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902163	adenocarcinoma	19	Deletion plus insertion	del Leu747-Ala750 (ins Pro)^a
921902171	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902172	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902175	adenocarcinoma	21	Point	858	CTG>CGG	Leu>Arg
921902187	adenocarcinoma	19	Deletion	del Glu746-Ala750

ins, Insertion of Amino Acid in parentheses