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Thermodynamic parameters for wild-type and designed sequences.
| ΔGo (Kcal/mol) |
Tm (°C) |
ΔCp° (Kcal/mol*K) |
ΔH° (Kcal/mol) |
m (Kcal/mol*M) |
|
|---|---|---|---|---|---|
| WT | 3.5 | 91 | 0.61 | 41 | 1.4 |
| FBAA | 14.9 | 144 | 0.83 | 107 | 2.3 |
| DRAA | 5.5 | 96 | 0.90 | 63 | 1.9 |
| DRNN | 16.2 | 142 | 1.08 | 128 | 3.4 |
Values for ΔG°, Tm, ΔCp°, ΔH°, and m were calculated by globally fitting a surface of chemical and thermal melts using the Gibbs-Helmholtz equations. See also Supplemental Figures 1 & 2.
