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Anterior mid-cingulate cortex (aMCC) connectivity with the ventral striatum (VS) mediated the relationship between insulin resistance (IR) and depressed mood, as determined by the BDI-II. A cluster in the left aMCC shows stronger connectivity with the left VS in individuals with higher IR. Individuals with higher HOMA-IR values also exhibited stronger connectivity between the left VS and insula, but this connectivity was not related to depressed mood.
