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. Author manuscript; available in PMC: 2013 Jun 6.
Published in final edited form as: Cell Metab. 2012 May 24;15(6):861–872. doi: 10.1016/j.cmet.2012.04.020

Figure 1. Deficiency of Akt3 promotes atherosclerosis in ApoE−/− mice.

Figure 1

(a) Representative images of en face oil red O staining of aortas of ApoE−/−Akt3−/− and ApoE−/− littermates (8 males and 4 females in each group), n=12. (b) (Left panel) Representative images of cross-sections of the aortic sinus stained with oil red O. (Right panel) Quantification of atheroma area. Six slides form different layers were taken for analysis from at least 3 hearts for each group. (c) (Left panel) CD68-positive macrophages (brown) in lesions of ApoE−/−Akt3−/− and ApoE−/− mice. (Right panel) Quantification of CD68-positive areas. (d) Fasting triglycerides levels of ApoE−/−Akt3−/− and ApoE−/− mice after 9 weeks on a Western diet. (e–g) Body weight, fasting cholesterol levels, and lipoprotein profiles from ApoE−/− and ApoE−/−Akt3−/− mice on a normal chow diet or a Western diet. Data represent means ± SEM.