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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neuropharmacology. 2012 May 9;63(3):486–493. doi: 10.1016/j.neuropharm.2012.04.025

Figure 3.

Figure 3

Activation of group I metabotropic gluatamate receptors generate suprathreshold depolarizations in somatostatin-expressing interneurons targeting layer I. A: example of an interneuron responding with firing to DHPG (10 μM) application recorded in a slice prepared from a CXCR4-EGFP mouse. B: similar result obtained from a DHPG responding EGPF-expressing cell in a slice obtained from a P8 GIN mouse. C: anatomical properties of the cell shown in B reveal it for a young Martinotti interneuron. Notice the localization of its soma in the lower layers and the dense axonal arborization and extensive targeting of layer I (gray). D: firing pattern of the cell shown in B and C. Current steps were +100 pA (upper trace) and +40 pA and −100 pA (lower traces).