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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Neuropharmacology. 2012 May 9;63(3):486–493. doi: 10.1016/j.neuropharm.2012.04.025

Figure 5.

Figure 5

DHPG-induced increase of the frequency of spontaneous GABAergic currents is mediated by metabotropic glutamate receptors expressed by neurons located deeper than layer I. A: summary graph of the effect of DHPG (50 μM, gray bar) and subsequent application of LY367385 (100 μM) in control slices. Notice the similarity of the effects to the ones shown in Figure 3. The upper insets show traces in control (left), in the presence of DHPG (middle), and in the presence of both DHPG and LY367385 (right). Glutamatergic ionotropic synaptic transmission was blocked by NBQX (20 μM) and D-AP5 (50 μM). B: as in A, but in surgically-treated slices to cut ascending GABAergic axon targeting layer I. Notice the complete abolishment of DHPG effects.