Table 2.

Effect of Neighborhood Deprivation on Survival and Second Primary Malignancy Outcomes among Oropharyngeal Cancer Patients in Adjusted Analyses

	Overall Survival	Disease-specific Survival	Disease-free Survival	Second Primary Malignancy
Variables Included in Each Model	HR (95%CI)	HR (95%CI)	HR (95%CI)	HR (95%CI)
Neighborhood Deprivation
(Ref=Low/Moderate)	1.59 (1.00-2.53)*	1.38 (0.78-2.46)	1.04 (0.63-1.74)	2.99 (1.46-6.11)*
Cancer Stage
(Ref=III/IV)	0.55 (0.22-1.37)	0.77 (0.22-2.74)	1.18 (0.49-2.80)	1.49 (0.51-4.38)
Cancer Treatment
(Ref=Multiple Modalities)	0.53 (0.34-0.85)*	0.29 (0.14-0.62)**	0.44 (0.26-0.77)*	0.74 (0.36-1.50)
Sex
(Ref=Male)	0.95 (0.51-1.75)	0.88 (0.42-1.87)	0.94 (0.50-1.78)	1.36 (0.52-3.56)
Race/Ethnicity
(Ref=Non-Hispanic White)	2.36 (1.47-3.79)**	2.82 (1.62-4.90)**	2.90 (1.73-4.87)**	0.99 (0.33-3.01)
Smoking Status
(Ref=Never Smoker)	2.61 (1.53-4.43)**	1.89 (1.03-3.48)*	1.58 (0.96-2.59)	1.78 (0.78-4.06)
Annual household income
<$25,000	2.08 (1.19-3.64)*	1.73 (0.85-3.53)	1.22 (0.65-2.32)	0.60 (0.19-1.86)
$25,000-74,900	1.06 (0.65-1.73)	0.91 (0.50-1.67)	0.90 (0.54-1.48)	1.31 (0.64-2.69)
(Ref=≥$75,000)
Age	1.04 (1.02-1.06)**	1.04 (1.01-1.07)*	1.05 (1.02-1.08)**	1.05 (1.01-1.08)*

Note: “Ref” is reference group.

^*p< 0.05

^**p< 0.001: HR=hazard ratio.