Table 1.
Association results for the 8 SNPs included in all 3 Stages of the study
| SNP | Effect/reference allele | Study | N | Frequency | OR (95% CI) | P | |||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Cases | Controls | Cases | Controls | Heterozygotes | Homozygotes | ||||
| rs1202524 | G/A | Stage 1 | 832 | 2682 | 0.12 | 0.09 | 1.47(1.21–1.78) | 2.25(0.97–5.21) | 2.3E-05 |
| Stage 2 | 1265 | 5189 | 0.35 | 0.32 | 1.07(0.94–1.22) | 1.31(1.07–1.59) | 1.4E-02 | ||
| Stage 3 | 6371 | 8686 | 0.28 | 0.26 | 1.06(0.98–1.13) | 1.10(0.97–1.25) | 7.2E-02 | ||
| Combined | 8468 | 16557 | 0.27 | 0.25 | 1.09(1.03–1.16) | 1.17(1.05–1.30) | 1.6E-04 | ||
| rs1202529 | G/C | Stage 1 | 824 | 2668 | 0.12 | 0.09 | 1.45(1.20–1.76) | 1.97(0.87–4.48) | 5.5E-05 |
| Stage 2 | 1265 | 5189 | 0.35 | 0.32 | 1.07(0.94–1.22) | 1.31(1.07–1.59) | 1.4E-02 | ||
| Stage 3 | 6366 | 8684 | 0.28 | 0.26 | 1.06(0.99–1.14) | 1.09(0.96–1.23) | 8.1E-02 | ||
| Combined | 8455 | 16541 | 0.27 | 0.25 | 1.10(1.03–1.16) | 1.16(1.04–1.29) | 2.4E-04 | ||
| rs17556883 | T/C | Stage 1 | 832 | 2680 | 0.35 | 0.40 | 0.77(0.65–0.91) | 0.67(0.52–0.85) | 1.9E-04 |
| Stage 2 | 1264 | 5188 | 0.54 | 0.56 | 0.88(0.75–1.03) | 0.83(0.70–1.00) | 5.3E-02 | ||
| Stage 3 | 6361 | 8663 | 0.52 | 0.52 | 0.94(0.87–1.03) | 0.96(0.87–1.06) | 3.3E-01 | ||
| Combined | 8457 | 16531 | 0.51 | 0.52 | 0.90(0.84–0.96) | 0.90(0.83–0.97) | 3.1E-03 | ||
| rs9397178 | G/A | Stage 1 | 832 | 2682 | 0.41 | 0.37 | 1.16(0.98–1.38) | 1.41(1.12–1.78) | 3.6E-03 |
| Stage 2 | 1265 | 5189 | 0.09 | 0.07 | 1.14(0.96–1.36) | 2.45(1.37–4.40) | 8.1E-03 | ||
| Stage 3 | 6369 | 8683 | 0.13 | 0.15 | 0.97(0.88–1.06) | 1.07(0.87–1.33) | 8.8E-01 | ||
| Combined | 8466 | 16554 | 0.15 | 0.16 | 1.03(0.96–1.10) | 1.28(1.10–1.49) | 1.9E-02 | ||
| rs12208947 | A/G | Stage 1 | 831 | 2534 | 0.41 | 0.37 | 1.16(0.97–1.38) | 1.48(1.17–1.88) | 1.3E-03 |
| Stage 2 | 1265 | 5187 | 0.15 | 0.13 | 1.09(0.94–1.26) | 1.34(0.89–2.04) | 1.0E-01 | ||
| Stage 3 | 6367 | 8684 | 0.17 | 0.19 | 0.96(0.89–1.04) | 0.97(0.80–1.16) | 3.0E-01 | ||
| Combined | 8463 | 16405 | 0.19 | 0.20 | 1.01(0.95–1.08) | 1.15(1.01–1.32) | 2.0E-01 | ||
| rs11663212 | A/C | Stage 1 | 832 | 2679 | 0.30 | 0.25 | 1.34(1.14–1.57) | 1.42(1.03–1.94) | 3.0E-04 |
| Stage 2 | 1265 | 5190 | 0.12 | 0.11 | 1.17(1.00–1.36) | 0.92(0.50–1.68) | 1.0E-01 | ||
| Stage 3 | 6358 | 8657 | 0.14 | 0.14 | 1.02(0.94–1.11) | 1.08(0.86–1.36) | 4.2E-01 | ||
| Combined | 8455 | 16526 | 0.15 | 0.15 | 1.10(1.03–1.17) | 1.16(0.97–1.39) | 3.7E-03 | ||
| rs10795561 | T/A | Stage 1 | 832 | 2681 | 0.29 | 0.26 | 1.16(0.99–1.37) | 1.55(1.16–2.08) | 2.1E-03 |
| Stage 2 | 1145 | 4705 | 0.36 | 0.34 | 1.12(0.98–1.29) | 1.16(0.94–1.44) | 7.4E-02 | ||
| Stage 3 | 6353 | 8653 | 0.34 | 0.34 | 1.00(0.93–1.08) | 1.08(0.97–1.21) | 3.2E-01 | ||
| Combined | 8330 | 16039 | 0.34 | 0.33 | 1.04(0.98–1.11) | 1.14(1.04–1.25) | 8.2E-03 | ||
| rs190262 | T/G | Stage 1 | 832 | 2681 | 0.16 | 0.13 | 1.25(1.05–1.50) | 1.84(1.12–3.01) | 1.2E-03 |
| Stage 2 | 1265 | 5190 | 0.13 | 0.11 | 1.19(1.02–1.38) | 1.30(0.81–2.11) | 1.5E-02 | ||
| Stage 3 | 6356 | 8663 | 0.11 | 0.12 | 0.93(0.86–1.01) | 1.06(0.79–1.42) | 2.1E-01 | ||
| Combined | 8453 | 16534 | 0.12 | 0.12 | 1.02(0.96–1.09) | 1.24(0.99–1.55) | 1.7E-01 | ||