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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Trends Mol Med. 2012 May 15;18(6):311–316. doi: 10.1016/j.molmed.2012.04.006

Figure 1. Density-dependent model of the evolution of acquired resistance.

Figure 1

Sensitive cells (blue) initially grow exponentially, but this growth slows due to density constraints. Resistant cells (red) arise through mutation. When treatment begins, the sensitive cells decline, leaving room for resistant cells to grow.