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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Trends Mol Med. 2012 May 15;18(6):311–316. doi: 10.1016/j.molmed.2012.04.006

Table 2.

The probability of treatment success, depending on tumor size and time spent at steady stateb

T=0 T=1 year T=10 years
Neutral
N=107 0.990 0.981 0.964
N=108 0.902 0.822 0.690
N=109 0.357 0.140 0.024
N=1010 0.0 0.0 0.0
Deleterious
N=107 0.992 0.987 0.986
N=108 0.925 0.881 0.867
N=109 0.459 0.283 0.241
N=1010 0.0 0.0 0.0
b

Parameter values: r=0.25, r’=0.1, d=d’=0.24, u=10−9. A deleterious resistant cell has a fitness disadvantage of 1% before treatment compared to sensitive cells (r̂= 0.99 r).