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. Author manuscript; available in PMC: 2013 Aug 1.

Published in final edited form as: Biochem Pharmacol. 2012 May 10;84(3):352–365. doi: 10.1016/j.bcp.2012.04.022

Table 2.

Potency and efficacy of nicotinic agonists for the zebrafish nAChR

	ACh	nicotine		cytisine
Receptor	EC₅₀ (µM)	EC₅₀ (µM)	^aI_max	EC₅₀ (µM)	^aI_max
^b α7	39 ± 3	27 ± 6	0.75 ± 0.04	15 ± 3	1.16 ± 0.06
α4β2	13 ± 1	6 ± 2	0.7 ± 0.1	0.47 ± 0.09	.26 ± 0.01
α2β2	40 ± 8	6 ± 1	0.3 ± 0.05	4.1 ± 0.3	0.09 ±0.01
α1β1_bεδ	48 ± 7	140 ± 50	0.13 ± 0.03	460 ± 20	0.13 ± 0.003
α3β4	73 ± 3	13 ± 6	0.17 ± 0.02	11 ± 1	0.12 ± 0.002

^a

Relative to ACh

^b

Responses of α7 receptors are measured as net charge. All other data are based on peak current amplitude.