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Inhibition of ACh-evoked peak currents and net charge responses by mecamylamine for zebrafish nAChR
| Peak current | Net charge | ||
|---|---|---|---|
| Receptor | IC50, µM | IC50, µM | Ratio |
| α3β4 | 0.6 ± 0.1 | .05 ± .01 | 12 |
| α1β1bεδ | 1.8 ± 0.21 | 0.6 ± .07 | 3.0 |
| α4β2 | 6.4 ± 1.5 | 0.29 ± 0.05 | 22 |
| α2β2 | 3.0 ± 0.7 | 3.5 ± 1.3 | 0.9 |
| α7 | 28 ± 11 | 13 ± 3 | 2.1 |
