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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Exp Mol Pathol. 2012 May 2;93(1):173–181. doi: 10.1016/j.yexmp.2012.04.021

Figure 4. Sirolimus modulates renal cell expression of E-cadherin, vimentin, and ZEB1/2 in HIVAN mice.

Figure 4

Renal cortical sections from CNS, TgNS, and TgS from the protocol A (n=6) were immunolabeled for E-cadherin, vimentin, and ZEB1/2.

A–C. Representative microphotographs of cortical sections of CNS, TgNS, and TgS labeled for E-cadherin. Renal epithelia in CNS (A) and TgS (C) showed +ve staining (dark brown, cytoplasmic) for E-cadherin; whereas, renal cells in TgNS (B) showed diminished staining for E-cadherin. X100

D–F. Representative microphotographs of cortical sections of CNS, TgNS, and TgS immunolabeled for vimentin. Renal epithelia in TgNS (E) showed +ve staining (brown, cytoplasmic) for vimentin; whereas, renal cells in CNS (D) and TgS (E) showed attenuated staining for vimentin. X100

G–I. Representative microphotographs of cortical sections of CNS, TgNS, and TgS immunolabeled for ZEB1/2. Renal epithelia in TgNS (E) showed +ve staining (brown, cytoplasmic) for ZEB1/2; whereas, renal cells in CNS (D) and TgS (E) showed diminished staining for ZEB1/2. X100