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α1-Adrenoceptor subtypes and their pharmacological characterization
| Gene | Receptor polypeptide | Phenotype | Affinity (mean pKB) Prazosin | Silodosin | Tamsulosin | RS-17053 |
|---|---|---|---|---|---|---|
| ADRA1A | α1a | α1A | 9.6 | 9.8 | 10.0 | 8.7 |
| α1L | 8.0 | 9.8 | 10.0 | 6.3 | ||
| ADRA1B | α1b | α1B | 10.2 | 8.0 | 9.3 | 7.8 |
| ADRA1D | α1d | α1D | 10.0 | 8.4 | 9.9 | 7.8 |
Affinity values are from Morishima et al. (2007).
