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Molecular model depicting the actions of acute ethanol on TLR4-MyD88 signalling. As shown by Wu et al. (2012), activation of TLR4-MyD88 signalling by alcohol may mediate sedative and motor impairment effects, as they were attenuated by the deletion of TLR4 and MyD88 genes, or by the pharmacological blocking of TLR4 with (+)-naloxone.
