. 2012 Mar;165(5):1361–1374. doi: 10.1111/j.1476-5381.2011.01580.x

Table 1.

Plasma parameters in lean and obese (ob/ob) mice treated with pentoxifylline (PTX) or placebo for 3 weeks

	Lean	Lean + PTX	ob/ob	ob/ob+ PTX
Fed state
Insulin (ng·mL⁻¹)	0.86 ± 0.13	0.92 ± 0.08	40.11 ± 8.15^*	33.77 ± 6.10^*
Adiponectin (µg·mL⁻¹)	9.32 ± 0.57	8.58 ± 0.28	11.63 ± 0.63^*	13.60 ± 0.71^*
IGF1 (ng·mL⁻¹)	182 ± 10	193 ± 11	226 ± 25	175 ± 18
Leptin (ng·mL⁻¹)	2.9 ± 1.2	1.7 ± 0.2	UD	UD
Glucose (mM)	7.7 ± 0.3	8.5 ± 0.3^†	9.9 ± 0.6^*	12.0 ± 0.8^*^†
Triglycerides (mM)	1.41 ± 0.10	1.52 ± 0.10	1.28 ± 0.14^*	0.99 ± 0.12^*
Total cholesterol (mM)	2.56 ± 0.08	2.50 ± 0.10	4.40 ± 0.12^*	4.59 ± 0.26^*
Glycerol (µM)	501 ± 25	655 ± 49^†	622 ± 52	677 ± 52
NEFAs (mM)	0.42 ± 0.04	0.56 ± 0.05^†	0.35 ± 0.03^*	0.33 ± 0.03^*
β-Hydroxybutyrate (mM)	0.08 ± 0.01	0.17 ± 0.01^†	0.11 ± 0.12	0.10 ± 0.26
AST (UI·L⁻¹)	89 ± 16	116 ± 26	279 ± 17^*	348 ± 29^*
ALT (UI·L⁻¹)	96 ± 26	135 ± 19^†	193 ± 27^*	288 ± 33^*^†
Fasted state
Insulin (ng·mL⁻¹)	0.49 ± 0.16	0.33 ± 0.08	3.95 ± 0.14^*	4.36 ± 0.42^*
Glucose (mM)	5.45 ± 0.70	4.74 ± 0.38	7.71 ± 0.60^*	8.15 ± 0.91^*
HOMA-IR	0.11 ± 0.03	0.08 ± 0.02	1.40 ± 0.23^*	1.47 ± 0.27^*
Triglycerides (mM)	2.30 ± 0.28	1.84 ± 0.13^†	1.52 ± 0.04^*	1.33 ± 0.06^*^†
Total cholesterol (mM)	2.78 ± 0.06	2.75 ± 0.14	5.72 ± 0.17^*	5.66 ± 0.09^*
Glycerol (µM)	839 ± 41	778 ± 33	849 ± 22	795 ± 19
NEFAs (mM)	1.66 ± 0.18	1.44 ± 0.14	1.26 ± 0.08^*	1.23 ± 0.08^*
β-Hydroxybutyrate (mM)	1.39 ± 0.12	1.21 ± 0.08	2.21 ± 0.24^*	2.41 ± 0.33^*

Blood was drawn in the fed or the fasted state, as specified in the Table. Results are means ± SEM for 12 mice per group, except for insulin, adiponectin, leptin and IGF1 (n = 7–10 mice per group).

Significantly different from lean mice (P < 0.05).

^†

Significantly different from untreated mice (P < 0.05).