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. 2012 Mar;165(5):1375–1389. doi: 10.1111/j.1476-5381.2011.01567.x

Figure 6.

Figure 6

Effect of chronic treatment with sertraline on the 5-HT2/5-HT1A heteroreceptor function. (A) On measuring the number of head-twitches induced by DOI injection (n = 12–15 mice per group), we found that HD mice exhibited fewer head-twitches when compared with WT and that chronic treatment with sertraline reduced DOI response only in WT mice. (B) The 5-HT1AR-mediated [35S]-GTP-γ-S binding (n = 6 mice per group) was increased by the non-selective 5-HT receptor agonist 5-CT, and expressed as OD over basal condition. This binding was reduced in HD animals but not affected by sertraline treatment. WT versus HD: **P < 0.01, ***P < 0.001; vehicle versus sertraline10 (chronic treatment): ++P < 0.01.