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. 2012 Mar;165(5):1401–1412. doi: 10.1111/j.1476-5381.2011.01641.x

Figure 1.

Figure 1

Blood concentration–time course of sEH inhibitors containing 1-N piperidyl urea moiety (A: TPAU and B: TPPU) and 4-(cyclohexyloxy) benzoic acid urea moiety (C: t-TUCB and D: t-CPUB). Blood was collected from tail vein of the four cynomolgus monkeys at time points 0, 0.25, 0.5, 1, 2, 3, 4, 8, 24, 48 and 72 h upon oral cassette dosing at 0.3 mg·kg−1. Each time point represents mean ± SD on all graphs. The dotted line represents the IC50 of each inhibitor in hepatic cytosol of cynomolgus monkeys (Table 2).