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Endothelin-1 (ET-1) inhibits TASK1 channels in Xenopus oocytes upon co-expression with endothelin receptors. Representative current recordings before and after exposure to 20 nM ET-1 are displayed for ETA (A, B) and ETB (E, F) receptors. (C, G) corresponding current voltage (I/V) relationships. (D, H) time course of TASK1 current blockade by 20 nM endothelin in the presence of ETA (D; n = 7) and ETB receptors (H; n = 7).
