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Upstream Rho kinase signalling in oocytes with TASK1 channels and ETA or ETB receptors. The small molecule Rac1 inhibitor (50 µM) was applied together with 20 nM ET-1. In addition, C3 toxin, an inhibitor of RhoA, was injected 3 h prior to the experiments (1 ng per oocyte) with ET-1 20 nM. Panel (A) shows the results for ETA receptors, and data obtained from ETB receptors are displayed in (B). Data are shown as mean ± SEM; *P < 0.05 versus ET-1 alone.
