Figure 5.

NCG is better than naringenin (NAR) in preserving trabecular microarchitecture in OVx mice. (A) Representative µCT images of femur distal femoral epiphysis of various experimental group (upper panel). µCT analysis of several trabecular parameters (BV/TV, Tb.N, CD, Tb.sp., Tb.pf and SMI) is presented in the lower two panels. (B) NCG supplementation has bone-conserving effect on trabecular microarchitecture of tibia metaphysis. Representative µCT images (upper panel) and quantification of trabecular parameters (BV/TV, Tb.N, Tb.th, Tb.sp., Tb.pf and SMI) are shown in the lower two panels. All values are expressed as mean ± SEM (n = 10 mice/group); *P < 0.05, **P < 0.01, ***P < 0.001 versus OVx + vehicle; ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 versus sham; ^xP < 0.05, ^yP < 0.01, ^zP < 0.001 versus NAR; ^pP < 0.05, ^qP < 0.01, ^rP < 0.001 versus E2; NCG-1, NCG-5, NCG at 1 or 5 mg·kg⁻¹·day⁻¹. NAR-1, NAR-5, naringenin at 1 or 5 mg·kg⁻¹·day⁻¹. E2-5, E2 at 5 µg·kg⁻¹·day⁻¹.