Figure 7.

Interaction between antipsychotic drugs and transmission-modulating agents on extracellular levels of L-glutamate and d-serine in the mPFC. Effects of microinjection of 1 ng·0.3 µL⁻¹ tetanus toxin (TeNT), perfusion with 1 µM TTX or 1 mM fluorocitrate (FLC) on antipsychotic (5 mg·kg⁻¹ clozapine and 1 mg·kg⁻¹ haloperidol)-induced release of (A) L-glutamate and (B) d-serine in the mPFC. Data are mean ± SEM (n = 6). *P < 0.05, **P < 0.01 versus control, by two-way anova with Tukey's multiple comparisons. Effects of microinjection of 1 ng·0.3 µL⁻¹ tetanus toxin, perfusion with 1 µM TTX or 1 mM fluorocitrate on 5 mg·kg⁻¹ clozapine-induced release of (C) L-glutamate and (D) d-serine in the mPFC. Data are mean ± SEM (n = 6). *P < 0.05, **P < 0.01 significantly different from pretreatment period, by manova with Tukey's multiple comparison. AUC, area under curve.