Figure 6.

Effect of AM3506 (100 nM) on ileal contractions in gene-deficient mice and in the presence of CB receptor antagonists. (A) AM3506 did not change EFS contractility in control or LPS(100 µg·kg⁻¹, i.p.)-treated FAAH^−/− mice. (B) AM251 (100 nM) and AM630 (300 nM) blocked the effect of AM3506 on ileal contractility in LPS treated CD1 mice. (C) AM3506 had no effect on ileal contractions of vehicle or LPS-treated CB₁^−/− mice; however, it decreased EFS contractility in C57BL/6N wild-type mice treated with LPS (100 µg·kg⁻¹, i.p.). *P < 0.05 compared with AM3506 in (B) and compared with vehicle in (C); n = 4–8 per group in all cases.