Table 1.
Distribution and functions of major integrins in leucocytes
| Integrin names | Ligands | Expression patterns | Major functions |
|---|---|---|---|
| αLβ2 (LFA-1, CD11a/CD18) | ICAM-1-5, TLN, Type I collagen | T cell, B cell, monocyte/macrophage, NK cell, DC, neutrophil, eosinophil | Migration of T cell, monocyte, neutrophil and eosinophil, activation and adhesion of T cell, DC and B cell, cytotoxicity of CTL and NK cell85–87 |
| αMβ2 (Mac-1, CR3, CD11b/CD18) | ICAM-1, ICAM-2, ICAM-4, iC3b, fibrinogen, factor X, heparin, laminin, LPS, zymosan, oligodeoxynucleotide, collagen, elastase | Monocyte/macrophage, DC, neutrophil, eosinophil, basophil, NK cell | Adhesion, activation and phagocytosis of macrophage, monocyte, neutrophil, eosinophil, basophil, DC and NK cell79,88 |
| αXβ2 (p150/95, CR4, CD11c/CD18) | C3bi, fibrinogen, collagen, CD23 heparin, LPS denatured protein | Monocyte/macrophage, neutrophil, NK cell | Adhesion and phagocytosis of monocyte/macrophage and neutrophil, adhesion of NK cell6,88 |
| αDβ2 (CD11d/CD18) | ICAM-3, VCAM-1 | Macrophage, eosinophil, T cell, NK cell | Adhesion and migration of macrophage and eosinophil, adhesion of T cell89 |
| α4β1 (VLA-4, CD49d/CD29) | VCAM-1, MAdCAM-1, fibrinogen, fibronectin, thrombospondin, pro-vWF, osteopontin, chondroitin | T cell, B cell, DC, monocyte/macrophage, NK cell, neutrophil, eosinophil, basophil | Migration and development of T cell and B cell, migration of monocyte/macrophage, eosinophil, and DC cell, adhesion of NK cell and neutrophil90–92 |
| α4β7 (LPAM-1, CD49d/CD-) | MAdCAM-1, VCAM-1, fibrinogen, fibronectin, osteopontin | T cell, B cell, monocyte/macrophage, NK cell, DC, eosinophil, basophil | Migration and development of T cell and B cell, migration of monocyte, macrophage, DC, eosinophil and NK cell90,93 |
| αEβ7 (HML-1, CD103/CD-) | E-cadherin | T cell, Treg, NK cell, DC, macrophage | Adhesion and activation of T cell and DC, cytotoxicity of T cell, suppressive function of Treg, recruitment of NK cell and macrophage94–96 |
| αVβ3 (CD51/CD61) | Vitronectin, ICAM-1, VCAM-1, PECAM-1, fibrinogen, fibronectin, vWF, LAP-TGF-β, thrombospondin | Monocyte, macrophage, DC, neutrophil | Migration of monocyte, macrophage and neutrophil, phagocytosis of DC and macrophage97,98 |
CR3, complement receptor-3; DC, dendritic cell; HML-1, human mucosal lymphocyte antigen-1; ICAM-1, intercellular adhesion molecule-1; LAP–TGF-β, latency-associated peptide–transforming growth factor-β complex; LFA-1, lymphocyte function-associated antigen-1; LPS, lipopolysaccharide; LPAM-1, lymphocyte Peyer's patch adhesion molecule-1; Mac-1, Macrophage-1 antigen; MAdCAM-1, mucosal addressin cell adhesion molecule-1; NK cell, natural killer cell; PECAM-1, platelet endothelial cell adhesion molecule-1; TLN, telencephalin; Treg, regulatory T cell; VCAM-1, vascular cell adhesion molecule-1; VLA-4, very late antigen-4; vWF, von Willebrand factor.