Figure 7.

Monocytes from patients with tuberculosis (TB) undergo death induced through mycobacterial antigen via Toll-like receptor 2 (TLR2). Monocytes were isolated from peripheral blood mononuclear cells by magnetic bead-labelled antibodies, and incubated with culture filtrate antigen extract (CFAE) from Mycobacterium tuberculosis H37Rv strain in the presence or absence of anti-TLR2 or anti-TLR4 antibodies for 4 hr at 37°. The bars denote cell death rate in cells from healthy controls (open bars) or TB patients (hatched bars). The P-value of the difference between bars is shown, n = 5.