Figure 5.

Transcriptional responses to acute Burkholderia pseudomallei infection in the mice with streptozotocin (STZ) -induced diabetes relative to uninfected diabetic mice. Hierarchical clustering of the expression profile of STZ-diabetic liver (DL) and STZ-diabetic spleen (DS) infected with B. pseudomallei at 16, 24 and 42 hr post-infection (p.i.) according to functional categories. The heat maps indicate the fold change in STZ-diabetic liver or STZ-diabetic spleen gene expression greater than (red) or less than (green) twofold at least once during the time course. Genes whose expression did not change are coloured in black. *Immune-related genes known to be associated with the general bacterial infection.