Table 1.
Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathways regulated in Burkholderia pseudomallei-infected streptozotocin-induced diabetic liver analysed by GeneTrail
| Categories | KEGG pathways | P-value |
|---|---|---|
| Up-regulated | Cytokine–cytokine receptor interaction | 1·86698e−05 |
| Jak-signal transducer and activator of transcription signalling pathway | 1·92797e−05 | |
| Adipocytokine signalling pathway | 0·0131694 | |
| Toll-like receptor signalling pathway | 3·63952e−09 | |
| Apoptosis | 1·37271e−05 | |
| Chemokine signalling pathway | 1·37271e−05 | |
| Antigen processing and presentation | 3·38894e−05 | |
| Mitogen-activated protein kinase signalling pathway | 0·000283262 | |
| Systemic lupus erythematosus | 8·11437e−05 | |
| Cell adhesion molecules | 0·000293927 | |
| Down-regulated | Drug metabolism – cytochrome P450 | 1·81645e−12 |
| Glycine, serine and threonine metabolism | 2·68347e−06 | |
| Tryptophan metabolism | 2·76687e−06 | |
| Methane metabolism | 2·22093e−05 | |
| Alanine, aspartate and glutamate metabolism | 2·42568e−05 | |
| ABC transporters | 0·00317722 | |
| Nitrogen metabolism | 0·0039838 | |
| PPAR signalling pathway | 0·0171655 | |
| Fatty acid metabolism | 0·00368175 | |
| Tricarboxylic acid cycle | 0·0933579 |