Table 2.

Kinetic profiles of host genes expression modulated by Burkholderia pseudomallei infection in streptozotocin (STZ) -induced diabetes and normoglycaemic models for both liver and spleen

		Fold change in transcript at hour post-infection1
		Normoglycaemic2						STZ-diabetic
		Liver			Spleen			Liver			Spleen
Gene symbol	GenBank	16hr	24hr	42hr	16hr	24hr	42hr	16hr	24hr	42hr	16hr	24hr	42hr
Toll-like receptor (TLR) and TLR-related
TLR2	NM_011905	107	72	25	7	8	3	–	93	23	–	–	–
TLR3	NM_126166	3	2	3	–	–	–	–	2	2	–	–	–
TLR4	NM_021297	–	–	2	–	–	3	–	–	2	–	–	–
TLR5	NM_016928	−5	−2	−5	–	–	–	–	–	–	–	–	–
TLR6	NM_011604	–	–	–	–	3	–	–	–	–	–	–	–
TLR7	NM_133211	–	–	–	3	5	3	–	–	–	–	–	–
TLR13	NM_205820	–	–	4	–	2	4	–	–	3	–	–	–
c-FOS	NM_010234	5	4	3	7	8	3	–	4	6	–	–	–
ICAM1	NM_010493	28	45	18	5	3	3	–	51	12	–	–	–
TRAF6	NM_009424	4	3	–	–	–	–	–	2	–	–	–	–
IRAK2	NM_172161	3	–	–	–	–	–	–	4	–	–	–	–
IRAK3	NM_028679	30	39	28	6	8	–	–	30	6	–	–	–
DUSP11	NM_028099	2	2	–	–	–	–	–	2	–	–	–	–
DUSP16	NM_130447	2	2	2	5	5	2	–	4	–	–	–	–
DUSP6	NM_026268	−3	–	–	–	–	–	–	–	–	–	–	–
DUSP8	NM_008748	8	4	2	–	–	–	–	8	3	–	–	–
CD14	NM_009841	106	259	151	10	20	5	–	171	48	–	–	–
MyD88	NM_010851	8	4	3	4	3	3	–	5	–	–	–	–
CD40	NM_170704	3	–	–	–	2	–	–	–	–	–	–	–
Tab2	NM_138667	–	–	2	–	–	–	–	–	–	–	–	–
SOCS1	NM_009896	12	9	6	10	8	5	–	8	4	–	–	3
SOCS2	NM_007706	–	0	5	–	4	–	–	–	–	–	–	–
SOCS3	NM_007707	11	5	–	13	11	–	–	11	6	–	–	3
TNFAIP3 (A20)	NM_009397	92	63	31	–	–	–	–	61	8	–	–	–
Cyokines and chemokines
MCP-1/CCL2	NM_011333	28	69	39	39	51	11	–	90	13	–	–	10
MIP1a/CCL3	NM_011337	3	5	–	39	48	12	–	4	–	–	–	–
MIP1b/CCL4	NM_013652	20	30	27	39	35	10	–	12	8	–	–	–
RANTES/CCL5	NM_013653	–	11	14	–	3	–	–	–	–	–	–	–
MCP-3/CCL7	NM_013654	17	11	12	88	107	40	–	15	7	–	–	19
CCL9	NM_011338	–	2	4	–	–	4	–	–	4	–	–	–
CCL12	NM_011331	3	4	13	18	25	27	–	3	6	–	–	6
CCL6	NM_009139	–	–	5	–	–	–	–	–	–	–	–	–
CCL24	NM_019577	–	–	4	–	–	–	–	–	4	–	–	–
CCL11	NM_011330	2	4	–	13	16	2	–	–	–	–	–	–
CCL17	NM_011332	–	–	–	3	6	–	–	–	–	–	–	–
CXCL1/KC/GROA	NM_008176	27	18	16	103	113	26	–	13	5	–	–	27
CXCL10/IP10	NM_021274	11	16	–	17	10	–	–	17	4	–	–	3
CXCL11	NM_019494	–	–	–	3	3	–	–	–	–	–	–	–
CXCL12	NM_013655	−3	−3	–	–	–	–	–	−4	−2	–	–	–
CXCL13	NM_018866	–	2	–	–	–	4	–	–	–	–	–	–
CXCL16	NM_023158	–	7	8	–	4	4	–	6	–	–	–	–
CXCL2/GROB	NM_009140	7	11	–	36	41	6	–	24	–	–	–	4
CXCL5/LIX	NM_009141	3	11	–	20	20	9	–	8	–	–	–	–
CXCL9/MIG	NM_008599	67	67	57	20	22	–	–	41	38	–	–	16
MIF	XM_147409	–	–	–	–	3	3	–	–	–	–	–	3
CSF1/M-CSF	NM_007778	2	3	5	2	2	–	–	–	–	–	–	–
CSF2	NM_009969	–	2	–	7	5	2	–	–	–	–	–	–
CSF3/G-CSF	NM_009971	9	15	–	29	62	–	–	24	–	–	–	–
Immune response
MD2/Ly96	NM_016923	–	2	–	–	–	–	–	3	3	–	–	–
Nfkb1	NM_008689	4	4	3	–	–	–	–	7	4	–	–	–
Nfkb2	NM_019408	3	3	3	–	–	–	–	–	–	–	–	–
Nfkbia/NFKBI	NM_010907	6	5	–	–	6	–	–	4	–	–	–	–
Nfkbib/IkB	NM_010908	3	3	–	–	–	–	–	3	–	–	–	–
Nfkbie/IkBE	NM_008690	3	13	13	–	–	–	–	13	6	–	–	–
Nfkbiz/INAP	NM_030612	24	5	7	–	8	–	–	4	–	–	–	–
IFNg	NM_008337	6	4	–	148	112	10	–	4	–	–	–	–
TNFa	NM_013693	3	6	2	9	5	3	–	11	–	–	–	–
TNFaip2	NM_009396	8	17	6	–	–	–	–	31	7	–	–	2
TNFaip3	NM_009397	92	63	31	–	–	–	–	61	8	–	–	–
NOS2	NM_010927	3	11	3	–	3	–	–	27	–	–	–	–
IRF1	NM_008390	14	19	9	4	4	4	–	27	12	3	–	4
IRF5	NM_012057	–	3	2	–	–	–	–	4	4	–	–	–
IRF7	NM_016850	5	6	5	7	10	7	3	5	8	–	–	6
IRF8	NM_008320	8	6	6	–	–	–	–	8	13	–	–	–
Jak2	NM_008413	2	2	3	–	2	–	–	4	3	–	–	–
Stat1	NM_009283	11	6	9	4	5	5	–	6	10	2	–	3
Stat2	NM_019963	–	–	2	4	5	4	–	3	3	–	–	2
Stat3	NM_011486	6	3	3	3	3	3	–	2	–	–	–	–
Map3k1	NM_011945	3	2	5	–	–	–	–	–	3	–	–	–
Map3k12	NM_009582	–	–	–	−2	–	–	–	–	–	–	–	–
Map3k14	NM_016896	3	2	–	–	–	–	–	3	2	–	–	–
Map3k8	NM_007746	4	3	2	–	6	–	–	3	–	–	–	–
Interleukin and interleukin-related
Il10	NM_010548	–	–	–	2	7	4	–	–	–	–	–	–
Il11	NM_008350	–	3	–	2	–	–	–	3	–	–	–	–
Il12rb1	NM_008353	–	–	–	3	4	–	–	–	–	–	–	–
Il15	NM_008357	–	–	–	5	4	2	–	–	–	–	–	–
Il15ra	NM_133836	–	–	–	4	7	4	–	3	–	–	–	2
Il18	NM_008360	–	−3	–	–	–	–	–	–	–	–	–	–
Il18bp	NM_010531	–	14	21	6	12	14	–	7	11	–	–	8
Il1a	NM_010554	–	–	–	8	9	–	–	–	–	–	–	–
Il1b	NM_008361	7	8	7	10	9	–	–	8	5	–	–	–
Il1r2	NM_010555	2	3	3	10	17	10	–	–	–	–	–	–
Il1rap	NM_008364	–	−6	−5	–	–	–	–	−4	–	–	–	–
Il23a	NM_031252	–	11	–	2	–	–	–	20	–	–	–	–
Il27	NM_145636	–	–	–	4	4	–	–	–	–	–	–	–
Il33	NM_133775	3	5	–	6	7	5	–	6	–	–	–	–
Il4i1	NM_010215	–	15	15	–	–	–	–	–	–	–	–	–
Il6	NM_031168	–	–	–	83	75	6	–	–	–	–	–	–
Il7	NM_008371	4	–	–	−3	−3	–	–	–	–	–	–	−2
Il8ra	NM_178241	–	–	–	2	2	5	–	–	–	–	–	–
Il8rb	NM_009909	–	–	–	3	5	5	–	–	–	–	–	–
Caspases cascades and cell death
caspase 1	NM_009807	2	3	5	–	–	–	–	3	5	–	–	–
caspase 2	NM_007610	2	–	3	–	–	–	–	3	2	–	–	–
caspase 4, caspase 11	NM_007609	7	9	12	5	11	4	–	9	6	–	–	–
caspase 6	NM_009811	–	−4	–	−2	–	–	–	−3	–	–	–	–
caspase 7	NM_007611	–	2	–	–	2	2	–	–	–	–	–	2
caspase 8	NM_009812	–	–	–	–	2	–	–	–	–	–	–	–
PARP12	NM_172893	6	5	4	8	8	4	–	5	5	–	–	4
PARP14	NM_145481	13	10	8	6	6	4	–	9	8	–	–	3
Creb3	NM_013497	3	3	–	–	–	–	–	4	2	–	–	–
Prkcb1	NM_008855	–	–	2	–	–	–	–	–	–	–	–	–
Bid	NM_007544	4	8	4	–	–	–	–	10	5	–	–	–
Tnfrsf1a	NM_011609	–	–	–	–	2	3	–	–	3	–	–	–
CD95/FAS	NM_007987	–	4	4	4	5	–	–	3	3	–	–	–
Tnfrsf22	NM_023680	3	6	12	–	–	–	–	10	10	–	–	–
Tnfsf10	NM_009425	2	4	3	4	4	2	–	3	4	–	–	3
1200002N14Rik	NM_027878	10	22	23	4	5	5	–	9	6	–	–	–
Bcl2a1a	NM_009742	8	6	8	–	–	–	–	5	7	–	–	–
Bcl2a1b	NM_007534	11	9	12	–	–	–	–	8	10	–	–	–
Bcl2a1d	NM_007536	12	10	13	–	–	–	–	7	9	–	–	–
Birc2	NM_007465	5	5	6	–	–	–	–	5	2	–	–	–
Birc3	NM_007464	5	4	–	–	–	–	–	5	–	–	–	–
Cd28	NM_007642	–	–	6	–	–	–	–	–	–	–	–	–
Cdkn1a	NM_007669	29	12	12	11	13	5	–	–	–	–	–	7
Ddit3	NM_007837	–	5	6	–	–	–	–	5	–	–	–	–
Fcgr3	NM_010188	–	2	5	–	–	–	–	–	3	–	–	–
Gadd45b	NM_008655	4	4	2	9	9	4	–	–	–	–	–	–
Litaf	NM_019980	6	3	3	3	4	3	–	5	3	–	–	–
Pnp	NM_013632	4	3	3	5	5	3	–	3	2	–	–	3
Prkr	NM_011163	8	4	3	7	6	4	–	5	3	–	–	2
Ripk2	NM_138952	31	17	6	3	–	–	–	38	5	–	–	–
Scotin	NM_025858	3	5	5	–	–	–	–	4	5	–	–	–
Serpina3g	XM_354694	39	30	28	7	8	8	–	24	30	–	–	3
Sox9	NM_011448	6	4	19	–	–	–	–	3	–	–	–	–
Tap1	NM_013683	7	7	6	3	3	–	–	14	14	2	–	3
Tap2	NM_011530	6	7	8	–	–	–	–	6	6	–	–	2
Inflammasome-related
NAIP2	NM_010872	–	2	4	–	–	–	–	2	2	–	–	–
NLRP3	NM_145827	–	–	–	2	–	–	–	–	–	–	–	–
CIIta (NLRA family)	NM_007575	–	4	4	–	–	–	–	4	7	–	–	–
NALP6/NLRP6	NM_133946	–	−4	−4	–	–	–	–	−2	–	–	–	–
NOD1	NM_172729	3	2	3	–	3	4	2	3	3	–	–	–
NOD2	NM_145857	–	–	–	3	3	2	–	–	–	–	–	–
P2X4	NM_011026	–	2	2	–	–	–	–	3	3	–	–	–
P2ry13	NM_028808	2	2	3	–	–	–	–	–	3	–	–	–
P2ry14	NM_133200	2	3	4	–	–	–	–	–	4	–	–	–
P2ry2	NM_008773	3	3	–	4	5	3	–	6	2	–	–	–
Panx1	NM_019482	–	6	6	–	–	–	–	4	6	–	–	–
Ctsz	NM_022325	–	–	–	–	–	3	–	–	3	–	–	–
Ctss	NM_021281	–	–	4	–	–	–	–	–	–	−2	–	–
Ctsc	NM_009982	–	–	5	–	–	3	–	–	5	–	–	–
Ctsf	NM_019861	–	−3	−3	–	–	–	–	−2	−2	–	–	−2
Ctsd	NM_009983	–	–	–	–	–	3	–	–	–	–	–	–
Atg16l2	XM_133655	6	6	5	–	–	–	–	7	3	–	–	–
Ifi205	NM_172648	4	2	3	3	3	–	–	–	3	–	–	–
Ifi27	NM_029803	–	2	5	–	2	3	–	–	–	–	–	–
Ifi30	NM_023065	–	–	4	–	–	–	–	–	4	–	–	–
Ifi35	NM_027320	3	3	–	–	4	2	–	3	3	–	–	–
Ifi44	NM_133871	5	5	4	3	–	2	–	4	5	–	–	–
Ifi47	NM_008330	28	18	15	–	–	–	–	31	20	–	–	3
Type 1 interferon (IFN) related
Oas1g	NM_011852	8	22	10	–	9	6	2	16	17	–	–	6
Oas2	NM_145227	2	3	2	9	10	6	–	2	2	–	–	–
Oasl1	NM_145209	13	22	12	19	18	6	–	15	15	–	–	7
Oasl2	NM_011854	3	4	4	6	7	5	–	5	6	–	–	5
S100a9	NM_009114	27	31	55	–	–	–	–	31	24	–	–	–
S100a8	NM_013650	26	37	60	–	–	–	–	33	27	–	–	–
S100a6	NM_011313	–	–	6	–	–	–	2	–	4	–	–	–
S100a11	NM_016740	–	5	5	–	–	2	–	5	5	–	–	–
Acute-phase proteins
Fgl1	NM_145594	3	3	3	–	–	–	–	–	–	–	–	–
Itih4	NM_018746	–	2	–	–	–	–	–	–	–	–	–	–
Cp	NM_007752	5	4	6	2	3	4	–	5	6	–	–	–
Hp	NM_017370	–	5	5	–	7	5	–	–	–	–	–	–
Pla2g7	NM_013737	–	2	3	–	–	–	–	–	2	–	–	–
Pla2g1b	NM_011107	–	–	–	25	29	–	–	–	–	–	–	–
Lbp	NM_008489	7	6	8	–	–	–	–	8	8	–	–	–
Saa1	NM_009117	13	13	13	–	–	–	–	–	–	–	–	–
Saa2	NM_011314	92	86	74	–	–	–	–	–	–	–	–	–
Saa3	NM_011315	124	121	112	36	91	94	–	–	–	–	–	56
Saa4	NM_011316	3	2	–	–	–	–	–	–	–	–	–	–
Fndc3b	NM_173182	6	3	5	–	3	–	–	2	3	–	–	–
Fndc3a	NM_207636	–	–	–	3	3	–	–	–	–	–	–	–
Fth1	NM_010239	–	–	–	–	2	2	–	–	–	–	–	–
Proteasomal degradation and peptidoglysis
Mmp13	NM_008607	3	–	6	49	26	10	–	–	6	–	–	6
Mmp14	NM_008608	–	–	6	2	4	3	–	–	3	–	–	–
Mmp2	NM_008610	−2	–	–	−4	−3	–	–	–	–	–	–	–
Mmp23	NM_011985	–	–	–	−3	−3	–	–	–	–	–	–	–
Mmp3	NM_010809	–	–	–	8	41	35	–	–	–	–	–	–
Mmp7	NM_010810	–	2	3	–	–	–	–	–	–	–	–	–
Mmp8	NM_008611	–	–	3	3	10	13	–	–	–	–	–	–
Mmp9	NM_013599	–	2	4	–	3	5	–	–	–	–	–	–
Ela2	NM_007919	–	–	–	20	21	–	–	–	–	–	–	–
Ela1	NM_033612	−7	−12	–	14	14	–	–	−2	−2	–	–	–
Ela3	NM_026419	–	–	–	34	57	–	–	–	–	–	–	–
Ubd	NM_023137	137	192	203	28	33	30	–	262	218	–	–	14
Psma4	NM_011966	–	–	–	–	2	2	–	–	–	–	–	–
Psma7	NM_011969	–	–	–	–	3	2	–	–	–	–	–	–
Psmb10	NM_013640	7	10	7	3	4	2	–	11	9	–	–	5
Psmb8	NM_010724	4	9	8	–	–	–	–	7	8	–	–	2
Psmb9	NM_013585	7	7	8	–	–	–	–	6	7	–	–	–
Psmd10	NM_016883	4	5	5	–	–	–	–	5	3	–	–	–
Psmd8	NM_026545	–	2	2	–	–	–	–	–	–	–	–	–
Psmd9	NM_026000	–	−2	–	–	–	–	–	–	–	–	–	–
Psme1	NM_011189	–	4	3	–	3	3	–	3	4	–	–	3
Prss1	NM_053243	–	–	–	45	67	–	–	–	–	–	–	–
Prss2	NM_009430	–	–	–	21	28	–	–	–	–	–	–	–
Prss23	NM_029614	–	–	–	–	3	2	–	–	–	–	–	–
Ube1dc1	NM_025692	2	2	–	–	–	–	–	3	3	–	–	–
Ube1l	NM_023738	6	11	8	3	3	2	–	9	8	–	–	–
Ube2l6	NM_019949	–	3	3	–	–	–	–	3	3	–	–	–
Ube2n	NM_080560	–	−2	–	–	–	–	–	–	–	–	–	–
Ube3b	NM_054093	–	−2	–	–	–	–	–	–	–	–	–	–
Ube4b	NM_022022	2	–	–	–	–	–	–	–	–	–	–	–
Complement system
C1r	NM_023143	–	–	–	–	2	–	–	–	–	–	–	–
C1qa	NM_007572	–	–	–	–	–	3	–	–	3	–	–	–
C1qb	NM_009777	–	–	–	–	–	3	–	–	4	–	–	–
C1qc	NM_007574	–	–	–	–	–	3	–	–	4	–	–	–
C1qtnf1	NM_019959	–	–	–	–	–	2	–	–	2	–	–	–
C2	NM_013484	–	2	2	–	4	5	–	–	2	–	–	–
C3	NM_009778	–	–	–	–	2	3	–	–	–	–	–	–
C4a	NM_011413	–	–	–	–	–	3	–	–	–	–	–	–
C4b	NM_009780	–	–	–	–	–	3	–	–	–	–	–	–
C4bp	NM_007576	–	–	2	–	–	–	–	–	–	–	–	–
C6	NM_016704	–	–	−4	–	–	–	–	–	–	–	–	–
C8a	NM_146148	–	−3	–	–	–	–	–	–	–	–	–	–
C8b	NM_133882	–	−3	−6	–	–	–	–	–	–	–	–	–
C9	NM_013485	–	−3	−4	–	–	–	–	–	–	–	–	–
C8g	XM_130127	–	−2	−4	–	–	–	–	–	–	–	–	–
Cfb	NM_008198	–	–	–	6	9	9	–	–	–	–	–	–
Cfhr1	NM_015780	–	−3	−2	–	–	–	–	−6	–	–	–	–
Masp1	NM_008555	–	−4	−3	–	–	–	–	−3	–	–	–	–
Masp2	XM_358353	–	−2	–	–	–	–	–	–	–	–	–	–
Properdin	XM_135820	–	–	2	–	–	–	–	–	–	–	–	–
Cd55	NM_010016	–	–	3	–	–	–	–	–	–	–	–	–
Cd93/c1qr	NM_010740	–	2	4	–	4	3	–	3	3	–	–	–
Sftpd	NM_009160	2	3	9	–	–	2	–	3	4	–	–	–
Fpr-rs2	NM_008039	13	12	17	7	10	10	–	10	7	–	–	–
Fpr1	NM_013521	–	–	2	–	6	5	–	–	–	–	–	–
Fibrinolysis and coagulation
Plau	NM_008873	–	–	–	–	–	5	–	–	6	–	–	–
Plaur	NM_011113	6	3	–	12	9	4	–	4	–	–	–	–
Plat	NM_008872	–	–	–	3	9	3	–	–	–	–	–	–
Klkb1	NM_008455	−3	−28	−5	–	–	–	–	−15	–	–	–	–
Klk1	NM_010639	–	–	–	–	27	–	–	–	–	–	–	–
Klk1b27	NM_020268	–	–	–	9	22	–	–	–	–	–	–	–
Klk1b4	NM_010915	–	–	−3	10	21	–	–	–	–	–	–	–
Klk1b5	NM_008456	–	–	–	14	26	–	–	–	–	–	–	–
Klk1b8	NM_008457	–	–	–	–	3	–	–	–	–	–	–	–
Klk4	NM_019928	–	–	–	–	3	–	–	–	–	–	–	–
F10	NM_007972	–	−2	–	3	6	4	–	–	–	–	–	–
F11	NM_028066	–	–	2	–	–	–	–	–	2	–	–	–
F13b	NM_031164	–	−7	−4	–	–	–	–	−3	–	–	–	–
F3	NM_010171	–	−2	–	6	5	–	–	–	–	–	–	–
F5	NM_007976	–	−3	–	–	–	–	–	−3	–	–	–	–
F7	NM_010172	–	−2	–	–	–	–	–	−3	–	–	–	–
F8	NM_007977	–	−2	–	–	–	–	–	–	–	–	–	–
Oxidative and anti-oxidative
Gpx2	NM_030677	–	–	6	–	–	–	–	–	3	–	–	–
Gpx3	NM_008161	–	2	4	–	–	5	–	3	–	–	–	–
Gpx7	NM_024198	–	–	2	–	–	–	–	–	2	–	–	–
Gsta4	NM_010357	–	−3	−2	–	–	–	–	–	–	–	–	–
Gstm1	NM_010358	–	−3	–	–	–	–	–	−2	–	–	–	–
Gstm2	NM_008183	–	–	–	–	–	2	–	–	–	–	–	–
Gstm3	NM_010359	–	−2	–	–	–	–	–	−2	–	–	–	–
Gstm4	NM_026764	−3	−5	−3	–	–	–	–	−4	–	–	–	–
Gstm6	NM_008184	–	−4	−2	–	–	–	–	−3	–	–	–	–
Gstm7	XM_359308	–	−5	–	–	–	–	–	−3	–	–	–	–
Gsto1	NM_010362	–	−3	–	–	–	–	–	−2	–	–	–	–
Gstt1	NM_008185	–	−5	−6	–	–	–	–	–	−3	–	–	–
Gstt2	NM_010361	−2	−3	–	–	–	–	–	–	–	–	–	–
Gstt3	NM_133994	–	−6	−2	–	–	–	–	–	–	–	–	–
Gstz1	NM_010363	–	−3	–	–	–	–	–	−2	–	–	–	–
Mgst3	NM_025569	–	−3	−3	–	−11	–	–	–	–	–	–	–
Gsr	NM_010344	–	–	–	–	–	2	–	–	–	–	–	–
Sod2	NM_013671	–	2	–	5	6	4	–	2	–	–	–	–
Tgm2	NM_009373	6	7	7	3	5	5	–	9	9	–	–	5
Noxo1	NM_027988	–	13	6	–	–	–	–	6	#N/A	–	–	–
Vnn3	NM_011979	13	25	10	2	–	–	–	27	11	–	–	–
Glycolysis/gluconeogenesis
Hk2	NM_013820	7	4	6	5	6	4	–	6	4	–	–	–
Hk3	NM_001033245	3	3	4	–	4	6	–	4	7	–	–	–
Khk	NM_008439	−2	–	−9	–	−2	–	–	–	–	–	–	–
Pfkl	NM_008826	–	–	–	–	3	–	–	–	–	–	–	–
Pfkp	NM_019703	–	–	–	–	3	3	–	–	3	–	–	–
Pgk1	NM_008828	–	–	–	–	4	3	–	–	–	–	–	–
Pfkm	NM_021514	−4	−4	−3	–	–	–	–	−3	–	–	–	–
Pgam1	NM_023418	–	−2	–	–	–	–	–	–	–	–	–	–
Eno1	NM_023119	–	−2	–	–	–	–	2	–	–	–	–	–
Eno2	NM_013509	–	–	–	–	3	–	–	–	–	–	–	–
Aldoa	NM_007438	−4	−3	−3	–	–	3	–	–	–	–	–	–
Aldoc	NM_009657	−2	−4	−5	–	–	–	–	–	–	–	–	–
Gapdh	NM_008084	–	–	–	–	2	–	–	–	–	–	–	2
Pkm2	NM_011099	–	5	7	–	2	3	–	6	11	–	–	–
Ldha	NM_010699	–	–	–	–	2	–	–	–	–	–	–	2
Pdk4	NM_013743	–	–	–	–	3	–	–	–	–	–	–	–
Pdhb	NM_024221	–	−2	−3	–	–	–	–	–	–	–	–	–
Pdk1	NM_172665	−3	−4	−3	–	–	–	–	−4	–	–	–	–
Pdk3	NM_145630	–	–	2	–	–	–	–	2	2	–	–	–
Pdk2	NM_133667	−2	−3	–	–	–	–	–	−3	–	–	–	–
Glycogen breakdown
Pygl	NM_133198	–	−10	−4	–	–	3	–	–	–	–	–	–
Pgm2	NM_028132	–	−2	–	–	4	–	–	–	–	–	–	–
Glycogen synthesis
Ugp2	NM_139297	−4	−7	−3	–	–	–	–	−6	–	–	–	–
Ugt2b1	NM_152811	–	−9	−41	–	–	–	–	−5	–	–	–	–
Ugt2b34	NM_153598	–	−6	−2	–	–	–	–	−6	–	–	–	–
Ugt3a2	NM_144845	–	−6	−10	–	–	–	–	−3	–	–	–	–
Ugt1a7c	NM_201410	–	–	–	−2	–	–	–	−4	–	–	–	–
Tricarboxylic acid cycle
Aco1	NM_007386	–	−3	–	–	–	–	–	−3	–	–	–	–
Idh1	NM_010497	–	–	−3	–	–	–	–	−3	–	–	–	–
Idh3b	NM_130884	–	−2	−2	–	–	–	–	–	–	–	–	–
Idh3a	NM_029573	−2	–	–	–	–	–	–	–	–	–	–	–
Sdhb	NM_023374	–	−3	−4	–	–	–	–	–	−2	–	–	–
Sdhc	NM_025321	–	−2	–	–	–	–	–	−2	–	–	–	–
Sdhd	NM_025848	–	−3	–	–	–	–	–	−3	–	–	–	–
Mdh1	NM_008618	–	−4	−3	–	–	–	–	−3	–	–	–	–
Fatty acid metabolism
Ehhadh	NM_023737	–	−6	–	–	–	–	–	–	–	–	–	–
Hadh	NM_008212	–	−3	−2	–	–	–	–	−2	–	–	–	–
Acat1	NM_144784	–	−6	−7	–	–	–	–	−3	−4	–	–	–
Acat2	NM_009338	–	−2	−3	–	–	–	–	–	–	–	–	–
Acat3	NM_153151	–	–	2	–	–	–	–	–	–	–	–	–
Valine, leucine and Isoleucine degradation
Hmgcs1	NM_145942	–	–	−2	–	–	–	–	–	–	–	–	–
Hmgcs2	NM_008256	–	−7	–	−3	–	–	–	–	–	–	–	–
Aldh1a1	NM_013467	–	−7	−2	–	–	–	–	−4	–	–	–	–
Aldh1a7	NM_011921	–	−2	–	–	–	–	–	–	–	–	–	–
Aldh1b1	NM_028270	−3	−9	–	–	–	–	–	−5	–	–	–	–
Aldh1l1	NM_027406	–	−3	−4	–	–	–	–	–	–	–	–	–
Aldh3b1	NM_026316	–	3	5	–	–	–	–	–	3	–	–	–
Aldh4a1	NM_175438	−2	−14	−6	–	–	–	–	−5	–	–	–	–
Aldh5a1	NM_172532	–	−2	–	–	–	–	–	–	–	–	–	–
Aldh6a1	NM_134042	–	−3	–	–	–	–	–	−2	–	–	–	–
Aldh8a1	NM_178713	−5	−8	–	–	–	–	–	−3	–	–	–	–
Cytochrome b
Cyp17a1	NM_007809	–	−3	–	–	–	–	–	–	–	–	–	–
Cyp1b1	NM_009994	–	–	–	–	5	5	–	3	–	–	–	–
Cyp1a2	NM_009993	−3	−11	−88	–	–	–	–	−7	−14	–	–	–
Cyp27a1	NM_024264	–	−2	−5	−2	−2	–	–	–	–	–	–	–
Cyp2a12	NM_133657	–	−3	–	–	–	–	–	–	–	–	–	–
Cyp2a4	NM_009997	−4	−5	−3	–	–	–	–	−6	–	–	–	–
Cyp2a5	NM_007812	−8	–	−10	–	–	–	–	−8	−4	–	–	–
Cyp2b10	NM_009999	–	–	2	–	–	–	–	–	–	–	–	–
Cyp2c29	NM_007815	–	−6	−49	–	–	–	–	−3	–	–	–	–
Cyp2c37	NM_010001	–	−8	−112	–	–	–	–	−4	–	–	–	–
Cyp2c39	NM_010003	–	−9	–	–	–	–	–	–	–	–	–	–
Cyp2c50	NM_134144	–	−11	−22	–	–	–	–	−3	−3	–	–	–
Cyp2c54	NM_206537	–	−4	−5	–	–	–	–	−5	−10	–	–	–
Cyp2c55	NM_028089	–	–	−3	–	–	–	–	–	–	–	–	–
Cyp2d10	NM_010005	–	−3	−3	–	–	–	–	–	–	–	–	–
Cyp2d13	NM_133695	−3	−5	−6	–	–	–	–	−3	–	–	–	–
Cyp2d22	NM_019823	–	−4	−3	–	–	2	–	−2	−3	–	–	–
Cyp2d26	NM_029562	–	−4	−2	–	–	–	–	−3	–	–	–	–
Cyp2d9	NM_010006	–	−3	−3	–	–	–	–	–	–	–	–	–
Cyp2e1	NM_021282	–	−3	−12	–	–	–	–	−2	–	–	–	–
Cyp2f2	NM_007817	–	−6	−11	–	–	–	–	–	–	–	–	–
Cyp2g1	NM_013809	−3	−3	−3	–	–	–	–	−3	–	–	–	–
Cyp2j9	NM_028979	–	−3	–	–	–	–	–	−3	–	–	–	–
Cyp3a11	NM_007818	–	−6	−5	–	–	–	–	−3	–	–	–	–
Cyp3a25	NM_019792	–	−7	−3	–	–	–	–	−3	–	–	–	–
Cyp4a10	NM_010011	–	−7	–	–	–	–	–	–	–	–	–	–
Cyp4a12	NM_177406	–	−2	−2	–	–	–	–	–	–	–	–	–
Cyp4a12b	NM_172306	–	−4	−4	–	–	–	–	–	–	–	–	–
Cyp4b1	NM_007823	−2	–	–	–	−3	–	–	–	–	–	–	–
Cyp4f14	NM_022434	−2	−12	−50	–	–	–	–	−4	–	–	–	–
Cyp4f15	NM_134127	−5	−14	−4	–	–	–	–	−12	−4	–	–	–
Cyp4v3	NM_133969	−3	−6	−3	–	–	2	–	−3	−3	–	–	–
Cyp51	NM_020010	–	–	−3	–	–	–	–	–	–	–	–	–
Cyp7a1	NM_007824	−176	−228	−211	–	–	–	–	−98	−39	–	–	–
Cyp7b1	NM_007825	–	–	–	–	3	4	–	–	–	–	–	–
Cyp8b1	NM_010012	–	−154	−137	–	–	–	–	−68	–	–	–	–
Miscellaneous
Faah	NM_010173	−3	−36	−5	–	–	–	–	−10	–	–	–	–
Car1	NM_009799	−2	−4	−5	–	–	−6	−2	−6	−7	–	–	–
Car13	NM_024495	4	7	8	5	8	4	–	4	3	–	–	–
Car14	NM_011797	−4	−13	−10	–	–	–	–	−3	−4	–	–	–
Car2	NM_009801	–	–	–	–	–	−11	–	–	–	–	–	–
Car3	NM_007606	–	−6	−263	–	–	–	–	−4	−34	–	–	–
Car4	NM_007607	2	12	–	–	5	2	–	–	–	–	–	–
Car5a	NM_007608	−7	−26	−11	–	–	–	–	−19	–	–	–	–
Akr1b3	NM_009658	–	–	3	–	–	–	–	–	–	–	–	–
Akr1b7	NM_009731	–	–	4	–	–	–	–	–	–	–	–	–
Akr1c14	NM_134072	−8	−23	−12	–	–	–	–	−26	–	–	–	–
Akr1c19	NM_001013785	–	−5	−8	–	–	–	–	−7	−6	–	–	–
Akr1c6	NM_030611	–	−17	−24	–	–	–	–	−5	–	–	–	–
Akr1e1	NM_018859	–	−3	–	–	–	–	–	−2	–	–	–	–
Akr7a5	NM_025337	–	−4	−2	–	–	–	–	–	–	–	–	–
Ddc	NM_016672	−14	−31	−4	–	–	–	–	−13	–	–	–	–
Apoa2	NM_013474	−3	−6	–	–	–	–	–	–	–	–	–	–
Apoa5	NM_080434	–	−24	–	–	–	–	–	−11	–	–	–	–
Aqp1	NM_007472	−3	–	–	–	−4	−12	–	–	–	–	–	–
Aqp11	NM_175105	−5	−5	−2	–	–	–	–	−3	−2	–	–	–
Aqp4	NM_009700	–	−3	−2	–	–	–	–	−2	–	–	–	–
Aqp8	NM_007474	−6	–	−6	–	–	–	–	–	–	–	–	–
Aqp9	NM_022026	−5	−24	−4	–	–	−4	–	−8	–	–	–	–
Arg1	NM_007482	–	−5	–	–	3	5	–	−4	–	–	–	–
Arg2	NM_009705	–	19	11	4	6	3	–	12	–	–	–	–

¹Modulated transcripts are classified according to functional groups. Only genes with a more than twofold change in B. pseudomallei-infected liver or spleen versus uninfected control tissue are shown; ‘–’, no significant change in gene expression.

²Data adopted from our recent work on genome-wide expression profiling of a murine acute melioidosis model.¹⁸