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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 May 8;1824(7):938–945. doi: 10.1016/j.bbapap.2012.04.012

Figure 3.

Figure 3

The IL-34:CSF-1R interface. (A) Sub-interface I which involves the α3 and α4 helices of IL-34 and the D2 domain of CSF-1R. Salt bridges are shown as dashes. (B) Sub-interface II which involves the α1 and α4 helices, the N- and C-terminal segments of IL-34, and the D3 domain of CSF-1R. (C) Biological activities of wild-type and mutant IL-34 in the M-NFS-60 cell proliferation assay. The luminescence signal (relative light unit), against the dose of proteins, is generated from reaction with luciferin in the presence of luciferase. Each data point represents the mean of triplicate and the standard deviation values are shown. The EC50 value for each protein was derived from the dose response curves.