Fig. 2.

Types of cerebral amyloid angiopathy pathology in two amyloid precursor protein (APP) transgenic (Tg) mouse models. a Punctate amyloid-β40 (Aβ₄₀) deposits (arrows) on microvessels of 12-month-old APP transgenic mice with three human APP mutations, the Swedish, Dutch and Iowa (Tg-SwDI; scale bar: 20 μm). b Cerebral amyloid angiopathy Aβ₄₀ deposit (arrows) in large penetrating artery in 20-month-old Tg2576 mouse (bar: 100 μm). c Spontaneous microhemorrhages (arrow) in 24 = month = old Tg2576 mouse, visualized using Prussian blue staining. (Scale bar: 200 μm). Inset: A higher magnification image (200×) of spontaneous microhemorrhages