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. 2012 Mar;165(6):1717–1736. doi: 10.1111/j.1476-5381.2011.01552.x

Figure 3.

Figure 3

Homer proteins function to regulate the association of protein complexes in the post-synaptic density. The Homer Ena/Vasp homology (EVH) domain as a consequence of the dimerization of their coiled-coiled domains couple mGluR1 and mGluR5 to inositol 1,4,5 triphosphate receptors and NMDA receptors via their interaction with SHANK which interacts with a protein complex involving GKAP and PSD95. The AMPA receptor is coupled to PSD95 via an interaction with TARP. The Homer EVH domain also couples mGluRs to the regulation of the actin cytoskeleton.